# Neuregulin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4316429](https://www.wikidata.org/wiki/Q4316429)  
**Source**: https://4ort.xyz/entity/neuregulin-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q02297)
3. Q20641742
4. [Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
5. [Identification of heregulin, a specific activator of p185erbB2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
6. [Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
7. [Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
8. [Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
10. [Receptor binding and biological activity of mammalian expressed sensory and motor neuron-derived factor (SMDF)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
11. [Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
12. [Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
13. [A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
14. [Binding of Neu Differentiation Factor with the Extracellular Domain of Her2 and Her3](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
16. [Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
17. [Identification of heregulin, a specific activator of p185erbB2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
18. [Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
19. [Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
21. [Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
22. [Segregation of receptor and ligand regulates activation of epithelial growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
23. [The neuregulin-I/ErbB signaling system in development and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
24. [Notch signaling is essential for ventricular chamber development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
25. [ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
26. [Neuregulins: versatile growth and differentiation factors in nervous system development and human disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
27. [The neuregulin-I/ErbB signaling system in development and disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
28. [Neuregulins: versatile growth and differentiation factors in nervous system development and human disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
29. [A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
30. [The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02297)
31. [Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02297&geneProductId=UniProtKB:Q02297)
32. ensembl Release 95