# Neural precursor cell expressed, developmentally down-regulated 4

> mammalian protein found in Mus musculus

**Wikidata**: [Q21984113](https://www.wikidata.org/wiki/Q21984113)  
**Source**: https://4ort.xyz/entity/neural-precursor-cell-expressed-developmentally-down-regulated-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P46935)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
5. [All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
6. [Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
7. [Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
8. [Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
9. [Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
10. [Identification of Developmentally Expressed Proteins That Functionally Interact with Nedd4 Ubiquitin Ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
11. [GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
12. [Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
13. [Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
14. [mGrb10 interacts with Nedd4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
15. [Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
16. [Interaction of WW Domains with Hematopoietic Transcription Factor p45/NF-E2 and RNA Polymerase II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
17. [N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
18. [Function of WW domains as phosphoserine- or phosphothreonine-binding modules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
19. [Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
21. [Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
22. [Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
23. [Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
24. [The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
25. [Abnormal development of the neuromuscular junction in Nedd4-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
26. [Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46935)
27. ensembl Release 106