# Nephrocystin 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21118162](https://www.wikidata.org/wiki/Q21118162)  
**Source**: https://4ort.xyz/entity/nephrocystin-4-q21118162


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O75161)
3. Q20641742
4. [Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
5. [Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
6. [The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
7. [Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
8. [Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
9. [Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
10. [Interaction of ciliary disease protein retinitis pigmentosa GTPase regulator with nephronophthisis-associated proteins in mammalian retinas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
11. [Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
12. [Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
13. [A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
14. [An organelle-specific protein landscape identifies novel diseases and molecular mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
15. [The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
16. [The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
18. [Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
20. [A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
21. [Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75161)
22. Ensembl Release 99