# NEDD8 activating enzyme E1 subunit 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21124708](https://www.wikidata.org/wiki/Q21124708)  
**Source**: https://4ort.xyz/entity/nedd8-activating-enzyme-e1-subunit-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13564)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13564&geneProductId=UniProtKB:Q13564)
5. [Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13564&geneProductId=UniProtKB:Q13564)
6. [APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13564)
7. [A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13564)
8. [The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13564)
9. [ASPP2 inhibits APP‐BP1‐mediated NEDD8 conjugation to cullin‐1 and decreases APP‐BP1‐induced cell proliferation and neuronal apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13564)
10. [APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13564)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13564)
12. [TRIP12 functions as an E3 ubiquitin ligase of APP-BP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13564)
13. [Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13564)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13564)
15. [APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13564&geneProductId=UniProtKB:Q13564)
16. [Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13564&geneProductId=UniProtKB:Q13564)
17. [Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13564)
18. Ensembl Release 99