# NEDD4 like E3 ubiquitin protein ligase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112132](https://www.wikidata.org/wiki/Q21112132)  
**Source**: https://4ort.xyz/entity/nedd4-like-e3-ubiquitin-protein-ligase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96PU5)
3. Q20641742
4. [Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
5. [The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
6. [Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
7. [The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
8. [Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
9. [Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
10. [Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
11. [The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
12. [HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
13. [Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
14. [Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
15. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
16. [Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96PU5&geneProductId=UniProtKB:Q96PU5)
19. [The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96PU5&geneProductId=UniProtKB:Q96PU5)
20. [Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96PU5&geneProductId=UniProtKB:Q96PU5)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
22. [Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
23. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96PU5&geneProductId=UniProtKB:Q96PU5)
24. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96PU5&geneProductId=UniProtKB:Q96PU5)
25. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
26. [Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96PU5&geneProductId=UniProtKB:Q96PU5)
27. [Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96PU5&geneProductId=UniProtKB:Q96PU5)
28. [Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96PU5&geneProductId=UniProtKB:Q96PU5)
29. [SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
30. [Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96PU5)
31. Ensembl Release 99