NEDD4 family E3 ubiquitin-protein ligase YER125W
type: Thing
description: fungal protein found in Saccharomyces cerevisiae S288c
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P39940
additional property: PropertyValue
  property ID: P361
  value: HECT, E3 ligase catalytic domain
additional property: PropertyValue
  property ID: P361
  value: WW domain superfamily
additional property: PropertyValue
  property ID: P361
  value: C2 domain superfamily
additional property: PropertyValue
  property ID: P527
  value: HECT domain
additional property: PropertyValue
  property ID: P527
  value: C2 domain
additional property: PropertyValue
  property ID: P527
  value: WW domain
additional property: PropertyValue
  property ID: P637
  value: NP_011051
additional property: PropertyValue
  property ID: P680
  value: ubiquitin-protein transferase activity
additional property: PropertyValue
  property ID: P680
  value: ubiquitin binding
additional property: PropertyValue
  property ID: P680
  value: phosphatidylinositol binding
additional property: PropertyValue
  property ID: P681
  value: Golgi apparatus
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: extrinsic component of cytoplasmic side of plasma membrane
additional property: PropertyValue
  property ID: P682
  value: cellular response to UV
additional property: PropertyValue
  property ID: P682
  value: positive regulation of fatty acid biosynthetic process
additional property: PropertyValue
  property ID: P682
  value: regulation of mRNA export from nucleus
additional property: PropertyValue
  property ID: P702
  value: RSP5
additional property: PropertyValue
  property ID: P703
  value: Saccharomyces cerevisiae S288c
additional property: PropertyValue
  property ID: P705
  value: YER125W
additional property: PropertyValue
  property ID: P3406
  value: S000000927
additional property: PropertyValue
  property ID: P7260
  value: 3.A.31.1.1
additional property: PropertyValue
  property ID: P7260
  value: 8.A.30.1.4
confidence:
  popularity graph score:
    score: 0.009
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 67
      unique citations norm: 0.026
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 67
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P39940
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797130
    source count: 1
    confidence: 0.2
    value label: HECT, E3 ligase catalytic domain
  P361:
    value: Q41797163
    source count: 1
    confidence: 0.2
    value label: WW domain superfamily
  P361:
    value: Q41797043
    source count: 1
    confidence: 0.2
    value label: C2 domain superfamily
  P361:
    value: Q24781918
    source count: 1
    confidence: 0.2
    value label: E3 ubiquitin-protein ligase, SMURF1 type
  P361:
    value: Q67123762
    source count: 1
    confidence: 0.2
    value label: P-P-bond-hydrolysis-driven transporter
  P527:
    value: Q24726575
    source count: 1
    confidence: 0.2
    value label: HECT domain
  P527:
    value: Q24774737
    source count: 1
    confidence: 0.2
    value label: C2 domain
  P527:
    value: Q24726881
    source count: 1
    confidence: 0.2
    value label: WW domain
  P637:
    value: NP_011051
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860441
    source count: 8
    confidence: 1.0
    value label: ubiquitin-protein transferase activity
  P680:
    value: Q14864232
    source count: 1
    confidence: 0.2
    value label: ubiquitin binding
  P680:
    value: Q14886045
    source count: 1
    confidence: 0.2
    value label: phosphatidylinositol binding
  P680:
    value: Q167149
    source count: 11
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q14840131
    source count: 1
    confidence: 0.2
    value label: transferase activity
  P681:
    value: Q83181
    source count: 1
    confidence: 0.2
    value label: Golgi apparatus
  P681:
    value: Q40260
    source count: 2
    confidence: 0.4
    value label: nucleus
  P681:
    value: Q14905148
    source count: 1
    confidence: 0.2
    value label: extrinsic component of cytoplasmic side of plasma membrane
  P681:
    value: Q22328113
    source count: 1
    confidence: 0.2
    value label: cellular bud tip
  P681:
    value: Q79899
    source count: 3
    confidence: 0.6
    value label: cytoplasm

value: Q14818058
source count: 1
confidence: 0.2
value label: cellular response to UV

value: Q14859629
source count: 1
confidence: 0.2
value label: positive regulation of fatty acid biosynthetic process

value: Q21112359
source count: 2
confidence: 0.4
value label: regulation of mRNA export from nucleus

value: Q14864932
source count: 1
confidence: 0.2
value label: positive regulation of proteasomal ubiquitin-dependent protein catabolic process

value: Q14876082
source count: 1
confidence: 0.2
value label: regulation of actin cytoskeleton organization

value: Q27540548
source count: 1
confidence: 0.2
value label: RSP5

value: Q27510868
source count: 1
confidence: 0.2
value label: Saccharomyces cerevisiae S288c

value: YER125W
source count: 1
confidence: 0.2

value: S000000927
source count: 1
confidence: 0.2

value: 3.A.31.1.1
source count: 1
confidence: 0.2

value: 8.A.30.1.4
source count: 0
confidence: 0.0

source: A bacterial genetic selection system for ubiquitylation cascade discovery
stated in qid: Q27728163
retrieved: 2019-05-09

source: Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast
stated in qid: Q27933356
retrieved: 2019-05-09

source: The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase
stated in qid: Q27937511
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p.
stated in qid: Q27936615
retrieved: 2019-05-09

source: Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site
stated in qid: Q27938247
retrieved: 2019-05-09

source: The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo
stated in qid: Q24677536
retrieved: 2019-05-09

source: Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family
stated in qid: Q24301029
retrieved: 2019-05-09

source: Transferrin receptor-like proteins control the degradation of a yeast metal transporter
stated in qid: Q27935937
retrieved: 2019-05-09

source: Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins.
stated in qid: Q27931057
retrieved: 2019-05-09

source: High-quality binary protein interaction map of the yeast interactome network
stated in qid: Q24651397
retrieved: 2019-05-09

source: Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.
stated in qid: Q27939550
retrieved: 2019-05-09

source: Peculiar protein-protein interactions of the novel endoplasmic reticulum membrane protein Rcr1 and ubiquitin ligase Rsp5.
stated in qid: Q27936431
retrieved: 2019-05-09

source: Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
stated in qid: Q27861116
retrieved: 2019-05-09

source: A comprehensive two-hybrid analysis to explore the yeast protein interactome
stated in qid: Q27861093
retrieved: 2019-05-09

source: PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance
stated in qid: Q27932832
retrieved: 2019-05-09

source: Proteome survey reveals modularity of the yeast cell machinery
stated in qid: Q27929510
retrieved: 2019-05-09

source: A global protein kinase and phosphatase interaction network in yeast.
stated in qid: Q27932206
retrieved: 2019-05-09

source: A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
stated in qid: Q24313174
retrieved: 2019-05-09

source: The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice
stated in qid: Q24308721
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.
stated in qid: Q27937366
retrieved: 2019-05-09

source: Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p
stated in qid: Q27937365
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.
stated in qid: Q27937366
retrieved: 2018-07-16

source: The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo
stated in qid: Q24677536
retrieved: 2018-07-16

source: The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions.
stated in qid: Q27939323
retrieved: 2019-05-09

source: Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
stated in qid: Q27653965
retrieved: 2019-05-09

source: Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics
stated in qid: Q27653964
retrieved: 2019-05-09

source: The proteome of Saccharomyces cerevisiae mitochondria
stated in qid: Q27653963
retrieved: 2019-05-09

wikidata id: Q27547704
domain: protein
level: standard
html url: https://4ort.xyz/entity/nedd4-family-e3-ubiquitin-protein-ligase-yer125w
markdown url: https://4ort.xyz/entity/nedd4-family-e3-ubiquitin-protein-ligase-yer125w.md
facts url summary: https://4ort.xyz/entity/nedd4-family-e3-ubiquitin-protein-ligase-yer125w/facts.json
facts url standard: https://4ort.xyz/entity/nedd4-family-e3-ubiquitin-protein-ligase-yer125w/facts.json
facts url full: https://4ort.xyz/entity/nedd4-family-e3-ubiquitin-protein-ligase-yer125w/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-08T07:00:45.614351Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:59:45.573236+00:00Z