# NEDD4 family E3 ubiquitin-protein ligase YER125W

> fungal protein found in Saccharomyces cerevisiae S288c

**Wikidata**: [Q27547704](https://www.wikidata.org/wiki/Q27547704)  
**Source**: https://4ort.xyz/entity/nedd4-family-e3-ubiquitin-protein-ligase-yer125w


## References

1. UniProt
2. Q20641742
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P39940)
4. [A bacterial genetic selection system for ubiquitylation cascade discovery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
5. [Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
6. [The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
8. [SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
9. [Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
10. [The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
11. [Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
12. [Transferrin receptor-like proteins control the degradation of a yeast metal transporter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
13. [Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
14. [High-quality binary protein interaction map of the yeast interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
15. [Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
16. [Peculiar protein-protein interactions of the novel endoplasmic reticulum membrane protein Rcr1 and ubiquitin ligase Rsp5.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
17. [Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
18. [A comprehensive two-hybrid analysis to explore the yeast protein interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
19. [PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
20. [Proteome survey reveals modularity of the yeast cell machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
21. [A global protein kinase and phosphatase interaction network in yeast.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
22. [A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
23. [The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
25. [Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
26. [Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940)
28. [Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940)
29. [The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940)
30. [The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
31. [Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
32. [Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
33. [The proteome of Saccharomyces cerevisiae mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
34. [The plasma membrane proteome of Saccharomyces cerevisiae and its response to the antifungal calcofluor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
35. [Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
36. [Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
37. [The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
38. [The ESCRT-III Adaptor Protein Bro1 Controls Functions of Regulator for Free Ubiquitin Chains 1 (Rfu1) in Ubiquitin Homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
39. [Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
40. [GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
41. [Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
42. [Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
43. [Ubp2 Regulates Rsp5 Ubiquitination Activity In Vivo and In Vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
44. [Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
45. [The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940)
46. [Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
47. [Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
48. [Rsp5p is required for ER bound Mga2p120 polyubiquitination and release of the processed/tethered transactivator Mga2p90.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
49. [G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)
50. [The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940)