# NEDD4 E3 ubiquitin protein ligase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21107331](https://www.wikidata.org/wiki/Q21107331)  
**Source**: https://4ort.xyz/entity/nedd4-e3-ubiquitin-protein-ligase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P46934)
3. Q20641742
4. [PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
6. [Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
7. [Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
8. [Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
9. [ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
10. [LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
11. [A Role for the Ubiquitin Ligase Nedd4 in Membrane Sorting of LAPTM4 Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
12. [HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
13. [Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
14. [Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
15. [Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
16. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
17. [Rak functions as a tumor suppressor by regulating PTEN protein stability and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
18. [Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
19. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
20. [SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
21. [Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
22. [The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
23. [Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
24. [Interaction of WW Domains with Hematopoietic Transcription Factor p45/NF-E2 and RNA Polymerase II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
25. [Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
26. [Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
27. [Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
29. [Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
30. [HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
31. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
33. [Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
34. [The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
35. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
36. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
37. [Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
38. [Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
39. [The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
40. [Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
41. [Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
42. [Ubiquitination regulates PTEN nuclear import and tumor suppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
43. [Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
44. [ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
45. [Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
46. [NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
47. [Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
48. [Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934)
49. [Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)
50. [Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934)