# Nedd4 Dmel_CG42279

> protein found in Drosophila melanogaster

**Wikidata**: [Q29817872](https://www.wikidata.org/wiki/Q29817872)  
**Source**: https://4ort.xyz/entity/nedd4-dmel-cg42279


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9VVI3)
3. Q20641742
4. [Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
5. [Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
7. [Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
8. [Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
9. [Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3)
11. [Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
13. [Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3)
14. [A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3)
15. [A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
16. [The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
17. [Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
18. [Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3)
19. [Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVI3&geneProductId=UniProtKB:Q9VVI3)
21. [Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
22. [Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
23. [The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVI3)
24. ensembl Release 106
25. Transporter Classification database