# Nectin cell adhesion molecule 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21132881](https://www.wikidata.org/wiki/Q21132881)  
**Source**: https://4ort.xyz/entity/nectin-cell-adhesion-molecule-2-q21132881


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q92692)
3. Q20641742
4. [A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
6. [Identification of CD112R as a novel checkpoint for human T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
7. [The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
8. [Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
9. [Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
10. [Nectin ectodomain structures reveal a canonical adhesive interface](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
11. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
12. [Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
13. [A secreted protein microarray platform for extracellular protein interaction discovery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
14. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
15. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
16. [Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
17. [Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692)
19. [Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
20. [The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
21. [The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692)
22. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692)
23. [Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
24. [Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
25. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692)
26. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692)
27. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
28. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
29. [Structural features of nectin-2 (HveB) required for herpes simplex virus entry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
30. [Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
31. [Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692)
32. Ensembl Release 99