# NCK adaptor protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21113662](https://www.wikidata.org/wiki/Q21113662)  
**Source**: https://4ort.xyz/entity/nck-adaptor-protein-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P16333)
3. Q20641742
4. [Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
6. [Receptor Protein Tyrosine Phosphatase-Receptor Tyrosine Kinase Substrate Screen Identifies EphA2 as a Target for LAR in Cell Migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
7. [Nck-1 interacts with PKR and modulates its activation by dsRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
8. [Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
9. [Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
10. [TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
11. [Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
12. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
13. [Cooperative interactions at the SLP-76 complex are critical for actin polymerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
14. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
15. [Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
16. [Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
17. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
18. [Characterization of interactions of Nck with Sos and dynamin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
19. [T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
20. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
21. [Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
22. [Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
23. [Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
24. [Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
25. [Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
26. [Ubiquitylation‐dependent downregulation of Nck regulates its functional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
27. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
28. [Interaction between the N-terminal SH3 domain of Nck-alpha and CD3-epsilon-derived peptides: non-canonical and canonical recognition motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
29. [Improved Two-Dimensional Reversed Phase-Reversed Phase LC-MS/MS Approach for Identification of Peptide-Protein Interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
30. [SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
31. [Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
32. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
33. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
34. [Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
35. [Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
36. [Modulation of protein translation by Nck-1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
37. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16333&geneProductId=UniProtKB:P16333)
38. [Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
39. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
40. [Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
41. [Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333)
42. Ensembl Release 99
43. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)