# National Human Genome Research Institute

> U.S. research institute, part of the National Instittutes of Health

**Wikidata**: [Q1634459](https://www.wikidata.org/wiki/Q1634459)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/National_Human_Genome_Research_Institute)  
**Source**: https://4ort.xyz/entity/national-human-genome-research-institute

## Summary
The National Human Genome Research Institute (NHGRI) is a U.S. research institute focused on human genome research, and it is part of the National Institutes of Health (NIH). It was originally established as the National Center for Human Genome Research in 1989 and later renamed.

## Key Facts
- The institute was founded in 1989 and was originally called the National Center for Human Genome Research until 1997.
- It is part of the United States National Institutes of Health.
- Its headquarters is located in Bethesda, Montgomery County, United States.
- The institute's website is https://www.genome.gov.
- It has the ROR identifier 00baak391 and the grid ID grid.280128.1.
- The institute operates under the ISNI identifier 0000000122339230.

## FAQs
### Q: What is the main purpose of the National Human Genome Research Institute?
A: It is a U.S. research institute focused on human genome research, part of the National Institutes of Health.

### Q: When was the National Human Genome Research Institute established?
A: It was founded in 1989, originally as the National Center for Human Genome Research.

### Q: Where is the National Human Genome Research Institute located?
A: It is headquartered in Bethesda, Montgomery County, United States.

## Why It Matters
The National Human Genome Research Institute plays a crucial role in advancing our understanding of human genetics and genomics. By conducting and supporting research on the human genome, the institute helps uncover the genetic basis of diseases, develop new diagnostic tools, and improve treatments. Its work has contributed significantly to the Human Genome Project and subsequent genomic research initiatives, which have transformed medical research and personalized medicine. The institute's research helps address complex health challenges by providing insights into genetic factors that influence health and disease, ultimately contributing to better health outcomes and medical advancements.

## Notable For
- It was the lead institute for the Human Genome Project, which successfully mapped the human genome.
- It has developed and maintained the GenBank database, a comprehensive repository of genetic sequences.
- The institute has pioneered research on genomic medicine and precision health approaches.
- It has established the ClinGen consortium to develop standardized clinical genome references.
- It has been instrumental in developing ethical, legal, and social implications (ELSI) research related to genomic technologies.

## Body
### Organization and Structure
The National Human Genome Research Institute operates as a research institute within the United States National Institutes of Health. It was originally established as the National Center for Human Genome Research on October 1, 1989, and was renamed to its current title in 1997. The institute is headquartered at the NIH campus in Bethesda, Maryland.

### Research Focus
The institute's primary focus is on human genome research, including the study of genetic variation, gene function, and genomic technologies. It conducts basic research as well as translational studies that bridge laboratory discoveries with clinical applications.

### Key Initiatives
The institute has been instrumental in several major scientific initiatives:
- The Human Genome Project (1990-2003), which successfully mapped the entire human genome
- The 1000 Genomes Project, which cataloged genetic variation in diverse human populations
- The ENCODE project, which identified functional elements in the human genome
- The Clinical Genome Resource (ClinGen) consortium, which develops standardized clinical genome references

### Resources and Databases
The institute maintains several key resources:
- GenBank, a comprehensive database of genetic sequences
- The dbGaP database for genetic and genomic data
- The NCBI's Entrez system for searching biological databases

### International Collaboration
NHGRI collaborates with international research organizations and participates in global genomic research initiatives, contributing to the advancement of genomic knowledge worldwide.

## References

1. [GRID](https://www.grid.ac/institutes/grid.280128.1)
2. GRID Release 2017-01-10
3. Virtual International Authority File
4. Freebase Data Dumps. 2013
5. Czech National Authority Database
6. GRID Release 2015-12-14
7. GRID Release 2016-12-06
8. UMLS 2023
9. Aligned ISNI and Ringgold identifiers for institutions