# NADPH oxidase 4

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562766](https://www.wikidata.org/wiki/Q28562766)  
**Source**: https://4ort.xyz/entity/nadph-oxidase-4-q28562766


## References

1. UniProt
2. Q20641742
3. [Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
4. [Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924V1&geneProductId=UniProtKB:Q924V1)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
8. [The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
9. [Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
10. [Subcellular localization of Nox4 and regulation in diabetes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
11. [The role of NOX2 and "novel oxidases" in airway chemoreceptor O(2) sensing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
12. [Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924V1&geneProductId=UniProtKB:Q924V1)
13. [Modulation of chronic hypoxia-induced chemoreceptor hypersensitivity by NADPH oxidase subunits in rat carotid body](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
14. [Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
15. [Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
16. [The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
17. [Reduced levels of cyclic AMP contribute to the enhanced oxidative stress in vascular smooth muscle cells from spontaneously hypertensive rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
18. [NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
19. [Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
20. [H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924V1)
21. ensembl Release 104