NADH:ubiquinone oxidoreductase subunit S4
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: metformin
additional property: PropertyValue
  property ID: P129
  value: metformin hydrochloride
additional property: PropertyValue
  property ID: P352
  value: O43181
additional property: PropertyValue
  property ID: P361
  value: NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial
additional property: PropertyValue
  property ID: P361
  value: NADH dehydrogenase ubiquinone Fe-S protein 4-like superfamily
additional property: PropertyValue
  property ID: P637
  value: NP_001304980
additional property: PropertyValue
  property ID: P637
  value: NP_002486
additional property: PropertyValue
  property ID: P637
  value: XP_016864980
additional property: PropertyValue
  property ID: P680
  value: oxidoreductase activity, acting on NAD(P)H
additional property: PropertyValue
  property ID: P680
  value: NADH dehydrogenase (ubiquinone) activity
additional property: PropertyValue
  property ID: P680
  value: NADH dehydrogenase (ubiquinone) activity
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: respiratory chain complex I
additional property: PropertyValue
  property ID: P681
  value: mitochondrion
additional property: PropertyValue
  property ID: P682
  value: regulation of protein phosphorylation
additional property: PropertyValue
  property ID: P682
  value: positive regulation of fibroblast proliferation
additional property: PropertyValue
  property ID: P682
  value: reactive oxygen species metabolic process
additional property: PropertyValue
  property ID: P702
  value: NDUFS4
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000296684
additional property: PropertyValue
  property ID: P705
  value: ENSP00000422177
additional property: PropertyValue
  property ID: P705
  value: ENSP00000424570
confidence:
  popularity graph score:
    score: 0.004
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 29
      unique citations norm: 0.011
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 29
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q19484
    source count: 1
    confidence: 0.2
    value label: metformin
  P129:
    value: Q27089363
    source count: 1
    confidence: 0.2
    value label: metformin hydrochloride
  P352:
    value: O43181
    source count: 1
    confidence: 0.2
  P361:
    value: Q24778180
    source count: 1
    confidence: 0.2
    value label: NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial
  P361:
    value: Q54442437
    source count: 1
    confidence: 0.2
    value label: NADH dehydrogenase ubiquinone Fe-S protein 4-like superfamily
  P637:
    value: NP_001304980
    source count: 1
    confidence: 0.2
  P637:
    value: NP_002486
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016864980
    source count: 1
    confidence: 0.2
  P680:
    value: Q21763012
    source count: 1
    confidence: 0.2
    value label: oxidoreductase activity, acting on NAD(P)H
  P680:
    value: Q21101247
    source count: 4
    confidence: 0.8
    value label: NADH dehydrogenase (ubiquinone) activity
  P680:
    value: Q21101247
    source count: 5
    confidence: 1.0
    value label: NADH dehydrogenase (ubiquinone) activity
  P680:
    value: Q21101247
    source count: 4
    confidence: 0.8
    value label: NADH dehydrogenase (ubiquinone) activity
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q22326958
    source count: 1
    confidence: 0.2
    value label: respiratory chain complex I
  P681:
    value: Q39572
    source count: 2
    confidence: 0.4
    value label: mitochondrion
  P681:
    value: Q14330614
    source count: 2
    confidence: 0.4
    value label: mitochondrial inner membrane
  P681:
    value: Q909199
    source count: 1
    confidence: 0.2
    value label: respirasome
  P682:
    value: Q14851946
    source count: 1
    confidence: 0.2
    value label: regulation of protein phosphorylation
  P682:
    value: Q14859635
    source count: 1
    confidence: 0.2
    value label: positive regulation of fibroblast proliferation
  P682:
    value: Q14863432
    source count: 1
    confidence: 0.2
    value label: reactive oxygen species metabolic process
  P682:
    value: Q14881090
    source count: 3
    confidence: 0.6
    value label: mitochondrial respiratory chain complex I assembly
  P682:
    value: Q14330969
    source count: 1
    confidence: 0.2
    value label: brain development
  P702:
    value: Q18029980
    source count: 1
    confidence: 0.2
    value label: NDUFS4

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000296684
source count: 1
confidence: 0.2

value: ENSP00000422177
source count: 1
confidence: 0.2

value: ENSP00000424570
source count: 1
confidence: 0.2

value: ENSP00000424993
source count: 1
confidence: 0.2

value: ENSP00000425967
source count: 1
confidence: 0.2

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I
stated in qid: Q24304454
retrieved: 2018-03-27

source: Respiratory complex I in brain development and genetic disease
stated in qid: Q24319013
retrieved: 2018-03-27

source: cAMP controls oxygen metabolism in mammalian cells
stated in qid: Q24298085
retrieved: 2018-03-27

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-09-10

source: Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I
stated in qid: Q24304454
retrieved: 2019-04-08

source: cAMP controls oxygen metabolism in mammalian cells
stated in qid: Q24298085
retrieved: 2019-04-08

source: Respiratory complex I in brain development and genetic disease
stated in qid: Q24319013
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns
stated in qid: Q24290607
retrieved: 2018-03-27

source: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification
stated in qid: Q24296439
retrieved: 2018-03-27

source: Accessory subunits are integral for assembly and function of human mitochondrial complex I.
stated in qid: Q32884468
retrieved: 2018-03-27

source: Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns
stated in qid: Q24290607
retrieved: 2019-04-08

source: Accessory subunits are integral for assembly and function of human mitochondrial complex I.
stated in qid: Q32884468
retrieved: 2019-04-08

source: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification
stated in qid: Q24296439
retrieved: 2019-04-08

source: Mutation in the NDUFS4 gene of complex I abolishes cAMP-dependent activation of the complex in a child with fatal neurological syndrome
stated in qid: Q24290793
retrieved: 2019-04-08

source: Clinical heterogeneity in patients with mutations in the NDUFS4 gene of mitochondrial complex I
stated in qid: Q24307521
retrieved: 2019-04-08

source: A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome
stated in qid: Q24290836
retrieved: 2019-04-08

source: Demonstration of a New Pathogenic Mutation in Human Complex I Deficiency: A 5-bp Duplication in the Nuclear Gene Encoding the 18-kD (AQDQ) Subunit
stated in qid: Q24309157
retrieved: 2019-04-08

source: cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed
stated in qid: Q22008627
retrieved: 2019-04-08

source: Demonstration of a New Pathogenic Mutation in Human Complex I Deficiency: A 5-bp Duplication in the Nuclear Gene Encoding the 18-kD (AQDQ) Subunit
stated in qid: Q24309157
retrieved: 2018-01-01

source: cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed
stated in qid: Q22008627
retrieved: 2018-01-01

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21120100
domain: protein
level: standard
html url: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-subunit-s4-q21120100
markdown url: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-subunit-s4-q21120100.md
facts url summary: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-subunit-s4-q21120100/facts.json
facts url standard: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-subunit-s4-q21120100/facts.json
facts url full: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-subunit-s4-q21120100/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-03T14:52:11.878445Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:12:18.107337+00:00Z