# NADH:ubiquinone oxidoreductase subunit S4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21120100](https://www.wikidata.org/wiki/Q21120100)  
**Source**: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-subunit-s4-q21120100


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1431)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1703)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O43181)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
7. [Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181)
8. [Respiratory complex I in brain development and genetic disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181)
9. [cAMP controls oxygen metabolism in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181)
12. [Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
13. [cAMP controls oxygen metabolism in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
14. [Respiratory complex I in brain development and genetic disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
16. [Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181)
17. [The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181)
18. [Accessory subunits are integral for assembly and function of human mitochondrial complex I.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181)
19. [Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
20. [Accessory subunits are integral for assembly and function of human mitochondrial complex I.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
21. [The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
22. [Mutation in the NDUFS4 gene of complex I abolishes cAMP-dependent activation of the complex in a child with fatal neurological syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
23. [Clinical heterogeneity in patients with mutations in the NDUFS4 gene of mitochondrial complex I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
24. [A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
25. [Demonstration of a New Pathogenic Mutation in Human Complex I Deficiency: A 5-bp Duplication in the Nuclear Gene Encoding the 18-kD (AQDQ) Subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
26. [cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43181)
27. [Demonstration of a New Pathogenic Mutation in Human Complex I Deficiency: A 5-bp Duplication in the Nuclear Gene Encoding the 18-kD (AQDQ) Subunit](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181)
28. [cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43181&geneProductId=UniProtKB:O43181)
29. Ensembl Release 99