NADH:ubiquinone oxidoreductase core subunit S3
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: O75489
additional property: PropertyValue
  property ID: P361
  value: NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily
additional property: PropertyValue
  property ID: P361
  value: NADH dehydrogenase, subunit C
additional property: PropertyValue
  property ID: P361
  value: NADH:ubiquinone oxidoreductase, 30kDa subunit, protein family
additional property: PropertyValue
  property ID: P527
  value: NADH:ubiquinone oxidoreductase, 30kDa subunit
additional property: PropertyValue
  property ID: P527
  value: NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
additional property: PropertyValue
  property ID: P637
  value: NP_004542
additional property: PropertyValue
  property ID: P680
  value: oxidoreductase activity, acting on NAD(P)H
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: electron transfer activity
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: mitochondrial membranes
additional property: PropertyValue
  property ID: P681
  value: myelin sheath
additional property: PropertyValue
  property ID: P682
  value: substantia nigra development
additional property: PropertyValue
  property ID: P682
  value: negative regulation of intrinsic apoptotic signaling pathway
additional property: PropertyValue
  property ID: P682
  value: reactive oxygen species metabolic process
additional property: PropertyValue
  property ID: P702
  value: NDUFS3
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000263774
additional property: PropertyValue
  property ID: P705
  value: ENSP00000434970
additional property: PropertyValue
  property ID: P705
  value: ENSP00000431588
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 24
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 24
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: O75489
    source count: 1
    confidence: 0.2
  P361:
    value: Q41798312
    source count: 1
    confidence: 0.2
    value label: NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily
  P361:
    value: Q24740993
    source count: 1
    confidence: 0.2
    value label: NADH dehydrogenase, subunit C
  P361:
    value: Q83134758
    source count: 1
    confidence: 0.2
    value label: NADH:ubiquinone oxidoreductase, 30kDa subunit, protein family
  P361:
    value: Q95350943
    source count: 1
    confidence: 0.2
    value label: NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site, protein family
  P527:
    value: Q24724519
    source count: 1
    confidence: 0.2
    value label: NADH:ubiquinone oxidoreductase, 30kDa subunit
  P527:
    value: Q24727502
    source count: 1
    confidence: 0.2
    value label: NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
  P637:
    value: NP_004542
    source count: 1
    confidence: 0.2
  P680:
    value: Q21763012
    source count: 1
    confidence: 0.2
    value label: oxidoreductase activity, acting on NAD(P)H
  P680:
    value: Q167149
    source count: 5
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q14358476
    source count: 1
    confidence: 0.2
    value label: electron transfer activity
  P680:
    value: Q14349613
    source count: 1
    confidence: 0.2
    value label: oxidoreductase activity
  P680:
    value: Q21103358
    source count: 3
    confidence: 0.6
    value label: NADH dehydrogenase activity
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q14860954
    source count: 1
    confidence: 0.2
    value label: mitochondrial membranes
  P681:
    value: Q187388
    source count: 1
    confidence: 0.2
    value label: myelin sheath
  P681:
    value: Q21541791
    source count: 4
    confidence: 0.8
    value label: mitochondrial respiratory chain complex I
  P681:
    value: Q3493378
    source count: 1
    confidence: 0.2
    value label: mitochondrial matrix
  P682:
    value: Q14914352
    source count: 1
    confidence: 0.2
    value label: substantia nigra development
  P682:
    value: Q14914425
    source count: 1
    confidence: 0.2
    value label: negative regulation of intrinsic apoptotic signaling pathway
  P682:
    value: Q14863432
    source count: 1
    confidence: 0.2
    value label: reactive oxygen species metabolic process
  P682:
    value: Q14881090
    source count: 1
    confidence: 0.2
    value label: mitochondrial respiratory chain complex I assembly
  P682:
    value: Q14599698
    source count: 1
    confidence: 0.2
    value label: negative regulation of cell growth

value: Q18029973
source count: 1
confidence: 0.2
value label: NDUFS3

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000263774
source count: 1
confidence: 0.2

value: ENSP00000434970
source count: 1
confidence: 0.2

value: ENSP00000431588
source count: 1
confidence: 0.2

value: ENSP00000432099
source count: 1
confidence: 0.2

value: ENSP00000433405
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease
stated in qid: Q24313044
retrieved: 2019-04-08

source: DJ-1 binds to mitochondrial complex I and maintains its activity
stated in qid: Q24324507
retrieved: 2019-04-08

source: TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex
stated in qid: Q24314040
retrieved: 2019-04-08

source: Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin
stated in qid: Q24299240
retrieved: 2019-04-08

source: LC-MS/MS as an alternative for SDS-PAGE in blue native analysis of protein complexes
stated in qid: Q24336337
retrieved: 2019-04-08

source: cDNA Sequence and Chromosomal Localization of the Remaining Three Human Nuclear Encoded Iron Sulphur Protein (IP) Subunits of Complex I: The Human IP Fraction Is Completed
stated in qid: Q24310766
retrieved: 2019-04-08

source: Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death
stated in qid: Q24296337
retrieved: 2019-04-08

source: Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns
stated in qid: Q24290607
retrieved: 2019-04-08

source: cDNA Sequence and Chromosomal Localization of the Remaining Three Human Nuclear Encoded Iron Sulphur Protein (IP) Subunits of Complex I: The Human IP Fraction Is Completed
stated in qid: Q24310766
retrieved: 2017-09-26

source: cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed
stated in qid: Q22008627
retrieved: 2017-09-26

source: GOA
stated in qid: Q28018111
retrieved: 2017-09-26

source: cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed
stated in qid: Q22008627
retrieved: 2019-04-08

source: Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits
stated in qid: Q24338844
retrieved: 2019-04-08

source: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification
stated in qid: Q24296439
retrieved: 2017-09-26

source: Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits
stated in qid: Q24338844
retrieved: 2017-09-26

source: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification
stated in qid: Q24296439
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis
stated in qid: Q24297593
retrieved: 2017-09-26

source: Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis
stated in qid: Q24297593
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21120104
domain: protein
level: standard
html url: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-core-subunit-s3-q21120104
markdown url: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-core-subunit-s3-q21120104.md
facts url summary: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-core-subunit-s3-q21120104/facts.json
facts url standard: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-core-subunit-s3-q21120104/facts.json
facts url full: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-core-subunit-s3-q21120104/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T18:06:12.238675Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:57:14.966657+00:00Z