NADH:ubiquinone oxidoreductase core subunit S1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: metformin
additional property: PropertyValue
  property ID: P129
  value: metformin hydrochloride
additional property: PropertyValue
  property ID: P352
  value: P28331
additional property: PropertyValue
  property ID: P361
  value: NADH:ubiquinone oxidoreductase, subunit G
additional property: PropertyValue
  property ID: P361
  value: 2Fe-2S ferredoxin-like superfamily
additional property: PropertyValue
  property ID: P361
  value: Molybdopterin oxidoreductase domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Molybdopterin oxidoreductase, 4Fe-4S domain
additional property: PropertyValue
  property ID: P527
  value: 2Fe-2S ferredoxin-type iron-sulfur binding domain
additional property: PropertyValue
  property ID: P527
  value: NADH-quinone oxidoreductase, chain G, C-terminal
additional property: PropertyValue
  property ID: P637
  value: NP_001186910
additional property: PropertyValue
  property ID: P637
  value: NP_001186911
additional property: PropertyValue
  property ID: P637
  value: NP_001186912
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P680
  value: NADH dehydrogenase activity
additional property: PropertyValue
  property ID: P680
  value: electron transfer activity
additional property: PropertyValue
  property ID: P681
  value: respirasome
additional property: PropertyValue
  property ID: P681
  value: mitochondrion
additional property: PropertyValue
  property ID: P681
  value: mitochondrial matrix
additional property: PropertyValue
  property ID: P682
  value: ATP synthesis coupled electron transport
additional property: PropertyValue
  property ID: P682
  value: ATP metabolic process
additional property: PropertyValue
  property ID: P682
  value: reactive oxygen species metabolic process
additional property: PropertyValue
  property ID: P702
  value: NDUFS1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000233190
additional property: PropertyValue
  property ID: P705
  value: ENSP00000392709
additional property: PropertyValue
  property ID: P705
  value: ENSP00000397760
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 22
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 22
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q19484
    source count: 1
    confidence: 0.2
    value label: metformin
  P129:
    value: Q27089363
    source count: 1
    confidence: 0.2
    value label: metformin hydrochloride
  P352:
    value: P28331
    source count: 1
    confidence: 0.2
  P361:
    value: Q24785516
    source count: 1
    confidence: 0.2
    value label: NADH:ubiquinone oxidoreductase, subunit G
  P361:
    value: Q41797154
    source count: 1
    confidence: 0.2
    value label: 2Fe-2S ferredoxin-like superfamily
  P361:
    value: Q83136390
    source count: 1
    confidence: 0.2
    value label: Molybdopterin oxidoreductase domain, protein family
  P361:
    value: Q83164163
    source count: 1
    confidence: 0.2
    value label: 2Fe-2S ferredoxin-type iron-sulfur binding domain, protein family
  P361:
    value: Q83133023
    source count: 1
    confidence: 0.2
    value label: NADH-quinone oxidoreductase, chain G, C-terminal domain, protein family
  P527:
    value: Q24726082
    source count: 1
    confidence: 0.2
    value label: Molybdopterin oxidoreductase, 4Fe-4S domain
  P527:
    value: Q24785042
    source count: 1
    confidence: 0.2
    value label: 2Fe-2S ferredoxin-type iron-sulfur binding domain
  P527:
    value: Q24721446
    source count: 1
    confidence: 0.2
    value label: NADH-quinone oxidoreductase, chain G, C-terminal
  P527:
    value: Q24783210
    source count: 1
    confidence: 0.2
    value label: NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
  P527:
    value: Q24727186
    source count: 1
    confidence: 0.2
    value label: Molybdopterin oxidoreductase domain
  P637:
    value: NP_001186910
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001186911
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001186912
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001186913
    source count: 1
    confidence: 0.2
  P637:
    value: NP_004997
    source count: 1
    confidence: 0.2
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P680:
    value: Q21103358
    source count: 1
    confidence: 0.2
    value label: NADH dehydrogenase activity
  P680:
    value: Q14358476
    source count: 2
    confidence: 0.4
    value label: electron transfer activity

value: Q14349613
source count: 2
confidence: 0.4
value label: oxidoreductase activity

value: Q14904851
source count: 1
confidence: 0.2
value label: 2 iron, 2 sulfur cluster binding

value: Q909199
source count: 1
confidence: 0.2
value label: respirasome

value: Q39572
source count: 2
confidence: 0.4
value label: mitochondrion

value: Q3493378
source count: 1
confidence: 0.2
value label: mitochondrial matrix

value: Q21541791
source count: 3
confidence: 0.6
value label: mitochondrial respiratory chain complex I

value: Q14349455
source count: 2
confidence: 0.4
value label: membrane

value: Q21117541
source count: 1
confidence: 0.2
value label: ATP synthesis coupled electron transport

value: Q14884614
source count: 1
confidence: 0.2
value label: ATP metabolic process

value: Q14863432
source count: 3
confidence: 0.6
value label: reactive oxygen species metabolic process

value: Q14881090
source count: 1
confidence: 0.2
value label: mitochondrial respiratory chain complex I assembly

value: Q14863429
source count: 2
confidence: 0.4
value label: regulation of mitochondrial membrane potential

value: Q18029965
source count: 1
confidence: 0.2
value label: NDUFS1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000233190
source count: 1
confidence: 0.2

value: ENSP00000392709
source count: 1
confidence: 0.2

value: ENSP00000397760
source count: 1
confidence: 0.2

value: ENSP00000399912
source count: 1
confidence: 0.2

value: ENSP00000409689
source count: 1
confidence: 0.2

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: Determination of the cDNA sequence for the human mitochondrial 75-kDa Fe-S protein of NADH-coenzyme Q reductase
stated in qid: Q24314671
retrieved: 2019-04-08

source: Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain
stated in qid: Q24295878
retrieved: 2019-04-08

source: cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed
stated in qid: Q22008627
retrieved: 2018-03-27

source: Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I
stated in qid: Q24304454
retrieved: 2018-03-27

source: Leigh syndrome associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFS1 gene
stated in qid: Q24299919
retrieved: 2018-03-27

source: cAMP controls oxygen metabolism in mammalian cells
stated in qid: Q24298085
retrieved: 2018-03-27

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed
stated in qid: Q22008627
retrieved: 2019-04-08

source: Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I
stated in qid: Q24304454
retrieved: 2019-04-08

source: Leigh syndrome associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFS1 gene
stated in qid: Q24299919
retrieved: 2019-04-08

source: cAMP controls oxygen metabolism in mammalian cells
stated in qid: Q24298085
retrieved: 2019-04-08

source: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification
stated in qid: Q24296439
retrieved: 2018-03-27

source: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification
stated in qid: Q24296439
retrieved: 2019-04-08

source: Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain
stated in qid: Q24295878
retrieved: 2018-03-27

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21109055
domain: protein
level: standard
html url: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-core-subunit-s1-q21109055
markdown url: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-core-subunit-s1-q21109055.md
facts url summary: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-core-subunit-s1-q21109055/facts.json
facts url standard: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-core-subunit-s1-q21109055/facts.json
facts url full: https://4ort.xyz/entity/nadh-ubiquinone-oxidoreductase-core-subunit-s1-q21109055/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-03T20:17:32.222761Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:12:06.018882+00:00Z