# Myeloid differentiation primary response gene 88

> mammalian protein found in Mus musculus

**Wikidata**: [Q14905922](https://www.wikidata.org/wiki/Q14905922)  
**Source**: https://4ort.xyz/entity/myeloid-differentiation-primary-response-gene-88


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P22366)
3. Q20641742
4. [Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
5. [Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
6. [The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
7. [Negative regulation of Toll-like-receptor signaling by IRF-4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
8. [Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
9. [MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
10. [A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
11. [Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
12. [The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
13. [Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
14. [Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
15. [A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
16. [Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
17. [Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
18. [Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
19. [Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
21. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22366)
22. [The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
24. [Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22366&geneProductId=UniProtKB:P22366)
26. [ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
27. [Probiotic Bacteria Induce Maturation of Intestinal Claudin 3 Expression and Barrier Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
28. [MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
29. [IRF-7 is the master regulator of type-I interferon-dependent immune responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
30. [Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
31. [Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
32. [Dectin-1 mediates the biological effects of beta-glucans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
33. [Identification of Lps2 as a key transducer of MyD88-independent TIR signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
34. [Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
35. [Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
36. [TIRAP: an adapter molecule in the Toll signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
37. [Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
38. [Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
39. [Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
40. [MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
41. [Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
42. [CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
43. [The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366)
44. ensembl Release 106