# MYD88 innate immune signal transduction adaptor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q1500000](https://www.wikidata.org/wiki/Q1500000)  
**Source**: https://4ort.xyz/entity/myd88-innate-immune-signal-transduction-adaptor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q99836)
3. Q20641742
4. [IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
5. [Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
6. [AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
7. [Functional assessment of the mutational effects of human IRAK4 and MyD88 genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
8. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
9. [Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
10. [Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
11. [The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
12. [The apoptotic signaling pathway activated by Toll-like receptor-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
13. [Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
14. [Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
15. [Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
16. [MAPPIT analysis of TLR adaptor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
17. [Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
18. [Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
19. [The Brucella TIR-like protein TcpB interacts with the death domain of MyD88](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
20. [DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
21. [Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
22. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
23. [TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
24. [Characterization of Pellino2, a substrate of IRAK1 and IRAK4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
25. [SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
26. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
27. [The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
28. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
29. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
30. [A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
32. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
33. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
34. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
35. [The Brucella TIR-like protein TcpB interacts with the death domain of MyD88](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q99836)
36. [Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
37. [Expression of the Bcl-2 protein BAD promotes prostate cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
38. [Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
39. [Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
40. [HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
41. [The cloning and characterization of human MyD88: a member of an IL-1 receptor related family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
42. [Identification of MyD88 as a novel target of miR‐155, involved in negative regulation of Helicobacter pylori‐induced inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
43. [The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836)
44. Ensembl Release 99
45. Identifiers.org