# MYCN proto-oncogene, bHLH transcription factor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6951383](https://www.wikidata.org/wiki/Q6951383)  
**Source**: https://4ort.xyz/entity/mycn-proto-oncogene-bhlh-transcription-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04198)
3. Q20641742
4. [Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
6. [Human proto-oncogene N-myc encodes nuclear proteins that bind DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
7. [Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
8. [Functional interaction of Yaf2 with the central region of MycN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
9. [Drugging MYCN through an allosteric transition in Aurora kinase A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
10. [N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
11. [Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
12. [Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
13. [SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
14. [Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
15. [p14ARF interacts with N-Myc and inhibits its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
16. [Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
17. [The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
18. [N-MYC regulates focal adhesion kinase expression in human neuroblastoma.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
19. [N-MYC regulates focal adhesion kinase expression in human neuroblastoma.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04198&geneProductId=UniProtKB:P04198)
20. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04198&geneProductId=UniProtKB:P04198)
23. [Focal DNA copy number changes in neuroblastoma target MYCN regulated genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
24. [Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
25. [NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04198&geneProductId=UniProtKB:P04198)
26. [NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198)
27. Ensembl Release 99
28. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
29. UMLS 2023