# MYC proto-oncogene, bHLH transcription factor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q420267](https://www.wikidata.org/wiki/Q420267)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Myc)  
**Source**: https://4ort.xyz/entity/myc-proto-oncogene-bhlh-transcription-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P01106)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
7. [Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
8. [Identification of Mad as a repressor of the human telomerase (hTERT) gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01106&geneProductId=UniProtKB:P01106)
9. [Identification of Mad as a repressor of the human telomerase (hTERT) gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
10. [PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
11. [AP4 encodes a c-MYC-inducible repressor of p21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
12. [Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
13. [Yaf2 inhibits Myc biological function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
14. [Sirt1 deacetylates c-Myc and promotes c-Myc/Max association](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
15. [Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
16. [Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
17. [Fbw7 and Usp28 regulate myc protein stability in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
18. [The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
19. [Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
20. [The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
21. [Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
22. [Noninvasive molecular imaging of c-Myc activation in living mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
23. [Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
24. [The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
25. [Proteomic profiling of Myc-associated proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
26. [Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
27. [Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
28. [Deterministic direct reprogramming of somatic cells to pluripotency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
29. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
30. [Sin3b interacts with Myc and decreases Myc levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
31. [Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
32. [A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
33. [A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
34. [c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
35. [Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
36. [The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
37. [NEMO stabilizes c‐Myc through direct interaction in the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
38. [Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
39. [HPV-18 E7 conjugates to c-Myc and mediates its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
40. [Targeting of Miz-1 is essential for Myc-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
41. [RETRACTED: Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
42. [CIP2A inhibits PP2A in human malignancies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
43. [The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
44. [IκB kinases increase Myc protein stability and enhance progression of breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
45. [HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
46. [DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
47. [SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
48. [Epstein-Barr virus nuclear antigen 3C interacts with and enhances the stability of the c-Myc oncoprotein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
49. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)
50. [Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01106)