# MYC proto-oncogene, bHLH transcription factor

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561625](https://www.wikidata.org/wiki/Q28561625)  
**Source**: https://4ort.xyz/entity/myc-proto-oncogene-bhlh-transcription-factor-q28561625


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P09416)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
5. [Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
6. [Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
7. [c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
8. [LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
9. [Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
10. [Downregulation of cytochromes P450 in growth-stimulated rat hepatocytes: role of c-Myc induction and impaired C/EBP binding to DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
12. [Characterization of rat c-myc and adjacent regions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
13. [Coordinated regulation of c-Myc and Max in rat liver development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
14. [Expression and subcellular localization of the Myc superfamily proteins: c-Myc, Max, Mad1 and Mxi1 in the epiphyseal plate cartilage chondrocytes of growing rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
15. [Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
16. [Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
17. [The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
18. [The expression of c-myc during follicular growth and luteal formation in the rat ovary in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
19. [Cross-species genome wide expression analysis during pluripotent cell determination in mouse and rat preimplantation embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
20. [Mitochondrial structure, function and dynamics are temporally controlled by c-Myc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
21. [c-Myc is required for the glucose-mediated induction of metabolic enzyme genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
22. [A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
23. [Oncosecretomics coupled to bioenergetics identifies α-amino adipic acid, isoleucine and GABA as potential biomarkers of cancer: Differential expression of c-Myc, Oct1 and KLF4 coordinates metabolic changes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
24. [The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
25. [tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
26. [CEBPD Suppresses Prolactin Expression and Prolactinoma Cell Proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
27. [Polysaccharides from Capsosiphon fulvescens Stimulate the Growth of IEC-6 Cells by Activating the MAPK Signaling Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
28. [Astilbin inhibits proliferation of rat aortic smooth muscle cells induced by angiotensin II and down-regulates expression of protooncogene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
29. [Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
30. [Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
31. [Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
32. [Malignant transformation of an epithelial cell by v-Src via tv-a-mediated retroviral infection: a new cell model for studying carcinogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
33. [Changes in Hypothalamic Expression of the Lin28/let-7 System and Related MicroRNAs During Postnatal Maturation and After Experimental Manipulations of Puberty](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
34. [Mammary gland morphology and gene expression differ in female rats treated with 17β-estradiol or fed soy protein isolate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
35. [Modulation of c-myc gene expression by extracellular stimuli in rat hepatoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
36. [Down-regulation of the c-myc proto-oncogene in inhibition of vascular smooth-muscle cell proliferation: a signal for growth arrest?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
37. [Combined Stimulation with the Tumor Necrosis Factorαand the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
38. [Alcohol increases c-myc mRNA and protein in skeletal and cardiac muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
39. [c-myc and skp2 Coordinate p27 Degradation, Vascular Smooth Muscle Proliferation, and Neointima Formation Induced by the Parathyroid Hormone-Related Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
40. [AP4 encodes a c-MYC-inducible repressor of p21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
41. [Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
42. [Antiproliferative Effect of c-myc Antisense Phosphorothioate Oligodeoxynucleotides in Malignant Glioma Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
43. [Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
44. [Pro-inflammatory cytokine interleukin-1β promotes the development of intestinal stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
45. [Growth hormone directly and indirectly stimulates articular chondrocyte cell growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
46. [Testosterone regulation of proto-oncogene c-myc expression in primary Sertoli cell cultures from prepubertal rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
47. [Transmural Pressure Loading Enhances Gastric Mucosal Cell Proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
48. [Effects of Ganoderma lucidum polysaccharides on IEC-6 cell proliferation, migration and morphology of differentiation benefiting intestinal epithelium healing in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
49. [Increased expression of the N-myc gene during normal and neoplastic rat liver growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)
50. [Effect of glutathione depletion and metallothionein gene expression on arsenic-induced cytotoxicity and c-myc expression in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09416)