# MutS homolog 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6717778](https://www.wikidata.org/wiki/Q6717778)  
**Source**: https://4ort.xyz/entity/muts-homolog-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P43246)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
5. [Purified human MSH2 protein binds to DNA containing mismatched nucleotides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
6. [hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
7. [Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
8. [Activation of Human MutS Homologs by 8-Oxo-guanine DNA Damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
9. [Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
10. [hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
11. [Analysis of the human MutLalpha.MutSalpha complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
12. [Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
13. [Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
14. [Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
15. [MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
16. [The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
17. [Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
18. [The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
19. [(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
20. [Evidence for involvement of HMGB1 protein in human DNA mismatch repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
21. [Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
22. [Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
23. [Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
24. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
25. [Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
26. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
27. [The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
28. [hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
29. [Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
30. [Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
31. [Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
32. [MCM9 Is Required for Mammalian DNA Mismatch Repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
33. [Human exonuclease I interacts with the mismatch repair protein hMSH2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
34. [The interaction of DNA mismatch repair proteins with human exonuclease I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
35. [HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
36. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
37. [Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
38. [ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
39. [hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
40. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
41. [Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
42. [ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
43. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
44. [The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
45. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
46. [The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43246)
47. [Purified human MSH2 protein binds to DNA containing mismatched nucleotides](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
48. [Transcription promotes contraction of CAG repeat tracts in human cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
49. [Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)
50. [Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43246&geneProductId=UniProtKB:P43246)