# MutS homolog 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q14911693](https://www.wikidata.org/wiki/Q14911693)  
**Source**: https://4ort.xyz/entity/muts-homolog-2-q14911693


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P43247)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
5. [Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
6. [HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
7. [Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
8. [MSH2 deficient mice are viable and susceptible to lymphoid tumours](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
9. [An Msh2 point mutation uncouples DNA mismatch repair and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
10. [Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
12. [ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
13. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
15. [ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
16. [An Msh2 point mutation uncouples DNA mismatch repair and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
17. [Mouse models for hereditary nonpolyposis colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
18. [Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
19. [Mouse models for hereditary nonpolyposis colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
20. [Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
21. [Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
22. [The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
23. [Severe attenuation of the B cell immune response in Msh2-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
24. [Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
25. [Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
26. [Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
27. [Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
28. [Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
29. [Female embryonic lethality in mice nullizygous for both Msh2 and p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
30. [No female embryonic lethality in mice nullizygous for Msh2 and p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
31. [Mitochondrial dysfunction and increased sensitivity to excitotoxicity in mice deficient in DNA mismatch repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
32. [DNA mismatch repair proteins promote apoptosis and suppress tumorigenesis in response to UVB irradiation: an in vivo study](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
33. [Mismatch Repair Deficiency Interferes with the Accumulation of Mutations in Chronically Stimulated B Cells and Not with the Hypermutation Process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
34. [Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
35. [Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
36. [Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
37. [Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
38. [Acceleration of lymphomagenesis in mismatch-repair deficient mice by exposure to genotoxic agents](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
39. [The Sμ Tandem Repeat Region Is Critical for Ig Isotype Switching in the Absence of Msh2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
40. [Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
41. [Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43247)
42. [HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
43. [Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
44. [Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
45. [Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
46. [Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
47. [The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
48. [The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
49. [Female embryonic lethality in mice nullizygous for both Msh2 and p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)
50. [Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43247&geneProductId=UniProtKB:P43247)