# MutL homolog 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q14911713](https://www.wikidata.org/wiki/Q14911713)  
**Source**: https://4ort.xyz/entity/mutl-homolog-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9JK91)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
5. [Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
8. [ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
9. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
10. [Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
11. [The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
12. [Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
13. [The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
14. [Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
15. [Genomic instability in mice lacking histone H2AX](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
16. [Meiotic failure in male mice lacking an X-linked factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
17. [Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
18. [Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
19. [Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
20. [Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
21. [Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
22. [ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
23. [Meiosis in mice without a synaptonemal complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
24. [Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
25. [Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
26. [Meiotic arrest and aneuploidy in MLH3-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
27. [Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
28. [Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
29. [Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
30. [Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
31. [The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
32. [The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
33. [Meiosis in mice without a synaptonemal complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
34. [Genomic instability in mice lacking histone H2AX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
35. [Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
36. [Chromosomal influence on meiotic spindle assembly: abnormal meiosis I in female Mlh1 mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
37. [Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
38. [Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
39. [Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91)
40. [Crossover and noncrossover pathways in mouse meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
41. [Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
42. [Meikin is a conserved regulator of meiosis-I-specific kinetochore function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
43. [MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
44. [Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
45. [A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
46. [Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
47. [Meiotic pachytene arrest in MLH1-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
48. [Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
49. [Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)
50. [Mlh1 mediates tissue-specific regulation of mitotic recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91)