# MutL homolog 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6716597](https://www.wikidata.org/wiki/Q6716597)  
**Source**: https://4ort.xyz/entity/mutl-homolog-1-q6716597


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P40692)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40692&geneProductId=UniProtKB:P40692)
6. [hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
7. [HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
8. [hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
9. [The interaction of DNA mismatch repair proteins with human exonuclease I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
10. [Pathophysiology of ulcer disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
11. [A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
12. [Analysis of the human MutLalpha.MutSalpha complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
13. [Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
14. [Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
15. [Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
16. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
17. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
18. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
19. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
20. [Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
21. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
22. [Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
23. [FANCJ/BACH1 Acetylation at Lysine 1249 Regulates the DNA Damage Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
24. [An empirical framework for binary interactome mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
25. [The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
26. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
27. [Thymosin beta 4 expression and nuclear transport are regulated by hMLH1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
28. [MCM9 Is Required for Mammalian DNA Mismatch Repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
30. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40692&geneProductId=UniProtKB:P40692)
31. [hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40692&geneProductId=UniProtKB:P40692)
32. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
33. [Mutation of a mutL homolog in hereditary colon cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40692&geneProductId=UniProtKB:P40692)
34. [Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40692&geneProductId=UniProtKB:P40692)
35. [Mutation of a mutL homolog in hereditary colon cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
36. [Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40692)
37. Ensembl Release 99
38. UMLS 2023