# Multiple endocrine neoplasia 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q14913043](https://www.wikidata.org/wiki/Q14913043)  
**Source**: https://4ort.xyz/entity/multiple-endocrine-neoplasia-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O88559)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
5. [miR-24 regulates menin in the endocrine pancreas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
6. [Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
7. [STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
9. [Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
10. [Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
11. [Menin prevents liver steatosis through co-activation of peroxisome proliferator-activated receptor alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
12. [Tumor suppressor Menin acts as a corepressor of LXRα to inhibit hepatic lipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
14. [Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
15. [The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
16. [Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
17. [The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
18. [Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
19. [Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
20. [Characterization of the mouse Men1 gene and its expression during development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
21. [PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
22. [Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
23. [Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
24. [Menin is required in cranial neural crest for palatogenesis and perinatal viability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
25. [Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
26. [Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
27. [Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
28. [Menin induces apoptosis in murine embryonic fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
29. [Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
30. [Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
31. [Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
32. [Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
33. [Menin is required in cranial neural crest for palatogenesis and perinatal viability](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
34. [Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
35. [A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
36. [p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
37. [Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
38. [Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus](http://www.ebi.ac.uk/QuickGO/annotations?protein=O88559&geneProductId=UniProtKB:O88559)
39. [Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
40. [Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
41. [A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
42. [p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88559)
43. ensembl Release 106
44. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)