# MRX complex nuclease subunit YMR224C

> fungal protein found in Saccharomyces cerevisiae S288c

**Wikidata**: [Q27553080](https://www.wikidata.org/wiki/Q27553080)  
**Source**: https://4ort.xyz/entity/mrx-complex-nuclease-subunit-ymr224c


## References

1. UniProt
2. Q20641742
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P32829)
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
5. [Complex formation and functional versatility of Mre11 of budding yeast in recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
7. [DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
8. [The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
9. [Saccharomyces cerevisiae Mre11 is a high-affinity G4 DNA-binding protein and a G-rich DNA-specific endonuclease: implications for replication of telomeric DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
10. [Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
11. [Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
12. [The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
13. [Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
14. [Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
15. [Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
16. [Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
17. [Proteome-wide protein interaction measurements of bacterial proteins of unknown function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
18. [Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
19. [Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
20. [DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
21. [The Rad50 coiled-coil domain is indispensable for Mre11 complex functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
22. [Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
23. [The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
24. [Distinct roles of two separablein vitroactivities of yeast Mre11 in mitotic and meiotic recombination](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
25. [Complex formation and functional versatility of Mre11 of budding yeast in recombination](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
27. [The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
28. [DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
30. [Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
31. [Distinct roles of two separablein vitroactivities of yeast Mre11 in mitotic and meiotic recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
32. [Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
33. [Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
34. [Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
35. [Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
36. [The proteome of Saccharomyces cerevisiae mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
37. [Meiotic chromosomes: it takes two to tango](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
38. [Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
39. [Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
40. [A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
41. [Mre11 mediates gene regulation in yeast spore development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
42. [Functions of the yeast meiotic recombination genes, MRE11 and MRE2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
43. [Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
44. [A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
45. [Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
46. [Mitochondrial Genome Maintenance: Roles for Nuclear Nonhomologous End-Joining Proteins in Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
47. [Meiotic chromosomes: it takes two to tango](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32829&geneProductId=UniProtKB:P32829)
48. [Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
49. [The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)
50. [Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32829)