MRE11A homolog A, double strand break repair nuclease
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: Carroll County
additional property: PropertyValue
  property ID: P361
  value: DNA double-strand break repair protein Mre11
additional property: PropertyValue
  property ID: P361
  value: Metallo-dependent phosphatase-like
additional property: PropertyValue
  property ID: P361
  value: Mre11, DNA-binding domain superfamily
additional property: PropertyValue
  property ID: P527
  value: Calcineurin-like phosphoesterase domain, ApaH type
additional property: PropertyValue
  property ID: P527
  value: Mre11, DNA-binding
additional property: PropertyValue
  property ID: P637
  value: NP_001297657
additional property: PropertyValue
  property ID: P637
  value: NP_061206
additional property: PropertyValue
  property ID: P637
  value: XP_006510111
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: manganese ion binding
additional property: PropertyValue
  property ID: P680
  value: DNA helicase activity
additional property: PropertyValue
  property ID: P681
  value: site of double-strand break
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: telomere
additional property: PropertyValue
  property ID: P682
  value: positive regulation of kinase activity
additional property: PropertyValue
  property ID: P682
  value: mitotic intra-S DNA damage checkpoint signaling
additional property: PropertyValue
  property ID: P682
  value: chromosome organization
additional property: PropertyValue
  property ID: P702
  value: Mre11a
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000034405
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000111295
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000116321
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 22
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 22
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q61216
    source count: 1
    confidence: 0.2
    value label: Carroll County
  P361:
    value: Q24780635
    source count: 1
    confidence: 0.2
    value label: DNA double-strand break repair protein Mre11
  P361:
    value: Q24721058
    source count: 1
    confidence: 0.2
    value label: Metallo-dependent phosphatase-like
  P361:
    value: Q54461320
    source count: 1
    confidence: 0.2
    value label: Mre11, DNA-binding domain superfamily
  P361:
    value: Q83164210
    source count: 1
    confidence: 0.2
    value label: Mre11, DNA-binding domain, protein family
  P361:
    value: Q5018780
    source count: 1
    confidence: 0.2
    value label: Calcineurin-like phosphoesterase
  P527:
    value: Q24722214
    source count: 1
    confidence: 0.2
    value label: Calcineurin-like phosphoesterase domain, ApaH type
  P527:
    value: Q24785306
    source count: 1
    confidence: 0.2
    value label: Mre11, DNA-binding
  P637:
    value: NP_001297657
    source count: 1
    confidence: 0.2
  P637:
    value: NP_061206
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006510111
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006510112
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006510114
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633858
    source count: 2
    confidence: 0.4
    value label: DNA binding
  P680:
    value: Q14873986
    source count: 1
    confidence: 0.2
    value label: manganese ion binding
  P680:
    value: Q14875005
    source count: 2
    confidence: 0.4
    value label: DNA helicase activity
  P680:
    value: Q21100483
    source count: 2
    confidence: 0.4
    value label: single-stranded DNA endodeoxyribonuclease activity
  P680:
    value: Q14818106
    source count: 2
    confidence: 0.4
    value label: protein C-terminus binding
  P681:
    value: Q14911997
    source count: 2
    confidence: 0.4
    value label: site of double-strand break
  P681:
    value: Q14817956
    source count: 2
    confidence: 0.4
    value label: nucleoplasm
  P681:
    value: Q14872779
    source count: 3
    confidence: 0.6
    value label: telomere

value: Q14911996
source count: 3
confidence: 0.6
value label: Mre11 complex

value: Q14817968
source count: 3
confidence: 0.6
value label: PML body

value: Q14866059
source count: 2
confidence: 0.4
value label: positive regulation of kinase activity

value: Q14911683
source count: 2
confidence: 0.4
value label: mitotic intra-S DNA damage checkpoint signaling

value: Q14818075
source count: 1
confidence: 0.2
value label: chromosome organization

value: Q5399999
source count: 2
confidence: 0.4
value label: sister chromatid cohesion

value: Q14818018
source count: 3
confidence: 0.6
value label: cellular response to DNA damage stimulus

value: Q18252372
source count: 1
confidence: 0.2
value label: Mre11a

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000034405
source count: 1
confidence: 0.2

value: ENSMUSP00000111295
source count: 1
confidence: 0.2

value: ENSMUSP00000116321
source count: 1
confidence: 0.2

value: ENSMUSP00000119999
source count: 1
confidence: 0.2

value: ENSMUSP00000149184
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
stated in qid: Q37104813
retrieved: 2019-04-08

source: The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
stated in qid: Q40146555
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-09-10

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells
stated in qid: Q28587544
retrieved: 2019-04-08

source: Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
stated in qid: Q24677047
retrieved: 2019-04-08

source: The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase
stated in qid: Q28512554
retrieved: 2019-04-08

source: Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
stated in qid: Q28511458
retrieved: 2018-07-16

source: Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice
stated in qid: Q28509807
retrieved: 2018-07-16

source: Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice
stated in qid: Q28509807
retrieved: 2019-04-08

source: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
stated in qid: Q24305512
retrieved: 2018-04-24

source: The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis
stated in qid: Q28592328
retrieved: 2019-04-08

source: Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
stated in qid: Q28513366
retrieved: 2019-04-08

source: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
stated in qid: Q24305512
retrieved: 2019-04-08

source: The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis
stated in qid: Q28592328
retrieved: 2018-09-10

source: Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
stated in qid: Q28511458
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21987712
domain: protein
level: standard
html url: https://4ort.xyz/entity/mre11a-homolog-a-double-strand-break-repair-nuclease
markdown url: https://4ort.xyz/entity/mre11a-homolog-a-double-strand-break-repair-nuclease.md
facts url summary: https://4ort.xyz/entity/mre11a-homolog-a-double-strand-break-repair-nuclease/facts.json
facts url standard: https://4ort.xyz/entity/mre11a-homolog-a-double-strand-break-repair-nuclease/facts.json
facts url full: https://4ort.xyz/entity/mre11a-homolog-a-double-strand-break-repair-nuclease/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-12T05:09:45.718132Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:33.893913+00:00Z