# MRE11A homolog A, double strand break repair nuclease

> mammalian protein found in Mus musculus

**Wikidata**: [Q21987712](https://www.wikidata.org/wiki/Q21987712)  
**Source**: https://4ort.xyz/entity/mre11a-homolog-a-double-strand-break-repair-nuclease


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q61216)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216)
6. [Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
7. [The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216)
9. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
10. [PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
11. [Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
12. [The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
13. [Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216)
14. [Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216)
15. [Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
16. [PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216)
17. [The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
18. [Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
19. [PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
20. [The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61216&geneProductId=UniProtKB:Q61216)
21. [Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61216)
22. ensembl Release 106