MRE11 homolog, double strand break repair nuclease
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P49959
additional property: PropertyValue
  property ID: P361
  value: DNA double-strand break repair protein Mre11
additional property: PropertyValue
  property ID: P361
  value: Metallo-dependent phosphatase-like
additional property: PropertyValue
  property ID: P361
  value: Mre11, DNA-binding domain superfamily
additional property: PropertyValue
  property ID: P527
  value: Mre11, DNA-binding
additional property: PropertyValue
  property ID: P527
  value: Calcineurin-like phosphoesterase domain, ApaH type
additional property: PropertyValue
  property ID: P637
  value: NP_001317276
additional property: PropertyValue
  property ID: P637
  value: NP_005581
additional property: PropertyValue
  property ID: P637
  value: NP_005582
additional property: PropertyValue
  property ID: P638
  value: 3T1I
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: manganese ion binding
additional property: PropertyValue
  property ID: P680
  value: DNA helicase activity
additional property: PropertyValue
  property ID: P681
  value: site of double-strand break
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: PML body
additional property: PropertyValue
  property ID: P682
  value: reciprocal meiotic recombination
additional property: PropertyValue
  property ID: P682
  value: DNA recombination
additional property: PropertyValue
  property ID: P682
  value: telomere maintenance via telomerase
additional property: PropertyValue
  property ID: P692
  value: PBB GE MRE11A 205395 s at fs.png
additional property: PropertyValue
  property ID: P702
  value: MRE11
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000325863
additional property: PropertyValue
  property ID: P705
  value: ENSP00000326094
additional property: PropertyValue
  property ID: P705
  value: ENSP00000385614
confidence:
  popularity graph score:
    score: 0.007
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 52
      unique citations norm: 0.02
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 52
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P49959
    source count: 1
    confidence: 0.2
  P361:
    value: Q24780635
    source count: 1
    confidence: 0.2
    value label: DNA double-strand break repair protein Mre11
  P361:
    value: Q24721058
    source count: 1
    confidence: 0.2
    value label: Metallo-dependent phosphatase-like
  P361:
    value: Q54461320
    source count: 1
    confidence: 0.2
    value label: Mre11, DNA-binding domain superfamily
  P361:
    value: Q83164210
    source count: 1
    confidence: 0.2
    value label: Mre11, DNA-binding domain, protein family
  P361:
    value: Q5018780
    source count: 1
    confidence: 0.2
    value label: Calcineurin-like phosphoesterase
  P527:
    value: Q24785306
    source count: 1
    confidence: 0.2
    value label: Mre11, DNA-binding
  P527:
    value: Q24722214
    source count: 1
    confidence: 0.2
    value label: Calcineurin-like phosphoesterase domain, ApaH type
  P637:
    value: NP_001317276
    source count: 1
    confidence: 0.2
  P637:
    value: NP_005581
    source count: 1
    confidence: 0.2
  P637:
    value: NP_005582
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005274065
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006718905
    source count: 1
    confidence: 0.2
  P638:
    value: 3T1I
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633858
    source count: 1
    confidence: 0.2
    value label: DNA binding
  P680:
    value: Q14873986
    source count: 1
    confidence: 0.2
    value label: manganese ion binding
  P680:
    value: Q14875005
    source count: 1
    confidence: 0.2
    value label: DNA helicase activity
  P680:
    value: Q21100483
    source count: 2
    confidence: 0.4
    value label: single-stranded DNA endodeoxyribonuclease activity
  P680:
    value: Q14818106
    source count: 1
    confidence: 0.2
    value label: protein C-terminus binding
  P681:
    value: Q14911997
    source count: 2
    confidence: 0.4
    value label: site of double-strand break
  P681:
    value: Q220599
    source count: 1
    confidence: 0.2
    value label: cytosol

value: Q14817968
source count: 3
confidence: 0.6
value label: PML body

value: Q40260
source count: 4
confidence: 0.8
value label: nucleus

value: Q79899
source count: 1
confidence: 0.2
value label: cytoplasm

value: Q14872801
source count: 2
confidence: 0.4
value label: reciprocal meiotic recombination

value: Q14862222
source count: 1
confidence: 0.2
value label: DNA recombination

value: Q15315123
source count: 2
confidence: 0.4
value label: telomere maintenance via telomerase

value: Q14866059
source count: 1
confidence: 0.2
value label: positive regulation of kinase activity

value: Q14911683
source count: 2
confidence: 0.4
value label: mitotic intra-S DNA damage checkpoint signaling

value: PBB GE MRE11A 205395 s at fs.png
source count: 0
confidence: 0.0

value: Q18029281
source count: 1
confidence: 0.2
value label: MRE11

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000325863
source count: 1
confidence: 0.2

value: ENSP00000326094
source count: 1
confidence: 0.2

value: ENSP00000385614
source count: 1
confidence: 0.2

value: ENSP00000376933
source count: 1
confidence: 0.2

value: ENSP00000439511
source count: 1
confidence: 0.2

source: ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
stated in qid: Q24298863
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95
stated in qid: Q24323459
retrieved: 2019-05-09

source: The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response
stated in qid: Q24316950
retrieved: 2019-05-09

source: MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response
stated in qid: Q28116225
retrieved: 2019-05-09

source: SAMHD1 acts at stalled replication forks to prevent interferon induction
stated in qid: Q57753937
retrieved: 2019-05-09

source: ATRX dysfunction induces replication defects in primary mouse cells
stated in qid: Q24339453
retrieved: 2019-05-09

source: SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
stated in qid: Q40082412
retrieved: 2019-05-09

source: ATM-dependent phosphorylation of ATF2 is required for the DNA damage response
stated in qid: Q24303597
retrieved: 2019-05-09

source: CDK targets Sae2 to control DNA-end resection and homologous recombination
stated in qid: Q24328867
retrieved: 2019-05-09

source: EXD2 promotes homologous recombination by facilitating DNA end resection
stated in qid: Q28119210
retrieved: 2019-05-09

source: UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
stated in qid: Q63383594
retrieved: 2019-05-09

source: Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
stated in qid: Q24313501
retrieved: 2019-05-09

source: MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
stated in qid: Q24299852
retrieved: 2019-05-09

source: MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair
stated in qid: Q24315682
retrieved: 2019-05-09

source: DNA end resection by CtIP and exonuclease 1 prevents genomic instability
stated in qid: Q24305549
retrieved: 2019-05-09

source: Huntingtin interacting proteins are genetic modifiers of neurodegeneration
stated in qid: Q21145230
retrieved: 2019-05-09

source: SIRT1 regulates the function of the Nijmegen breakage syndrome protein
stated in qid: Q24317230
retrieved: 2019-05-09

source: Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation
stated in qid: Q35800318
retrieved: 2019-05-09

source: NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
stated in qid: Q24316234
retrieved: 2019-05-09

source: CtIP tetramer assembly is required for DNA-end resection and repair
stated in qid: Q42152346
retrieved: 2019-05-09

source: Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations
stated in qid: Q27675521
retrieved: 2019-05-09

source: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
stated in qid: Q24305512
retrieved: 2019-05-09

source: Five dysfunctional telomeres predict onset of senescence in human cells
stated in qid: Q24299538
retrieved: 2019-05-09

source: Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks
stated in qid: Q24337442
retrieved: 2019-05-09

source: Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
stated in qid: Q24336328
retrieved: 2019-05-09

source: PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.
stated in qid: Q41792379
retrieved: 2019-05-09

source: TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres
stated in qid: Q28118158
retrieved: 2019-05-09

source: The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks
stated in qid: Q24311761
retrieved: 2017-10-17

source: GOA
stated in qid: Q28018111
retrieved: 2017-10-17

wikidata id: Q2073928
domain: protein
level: standard
html url: https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928
markdown url: https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928.md
facts url summary: https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928/facts.json
facts url standard: https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928/facts.json
facts url full: https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-13T16:22:27.065929Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:21:06.097547+00:00Z