# MRE11 homolog, double strand break repair nuclease

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2073928](https://www.wikidata.org/wiki/Q2073928)  
**Source**: https://4ort.xyz/entity/mre11-homolog-double-strand-break-repair-nuclease-q2073928


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49959)
3. Q20641742
4. [ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
6. [Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
7. [The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
8. [MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
9. [SAMHD1 acts at stalled replication forks to prevent interferon induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
10. [ATRX dysfunction induces replication defects in primary mouse cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
11. [SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
12. [ATM-dependent phosphorylation of ATF2 is required for the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
13. [CDK targets Sae2 to control DNA-end resection and homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
14. [EXD2 promotes homologous recombination by facilitating DNA end resection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
15. [UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
16. [Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
17. [MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
18. [MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
19. [DNA end resection by CtIP and exonuclease 1 prevents genomic instability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
20. [Huntingtin interacting proteins are genetic modifiers of neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
21. [SIRT1 regulates the function of the Nijmegen breakage syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
22. [Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
23. [NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
24. [CtIP tetramer assembly is required for DNA-end resection and repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
25. [Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
26. [PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
27. [Five dysfunctional telomeres predict onset of senescence in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
28. [Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
29. [Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
30. [PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
31. [TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
32. [The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959)
33. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959)
34. [Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959)
35. [ATM-dependent phosphorylation of nibrin in response to radiation exposure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
36. [The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
37. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959)
38. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
39. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
40. [Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
41. [Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
42. [A balance between elongation and trimming regulates telomere stability in stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
43. [RAD50 and NBS1 form a stable complex functional in DNA binding and tethering](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
44. [Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
45. [Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
46. [Isolation and characterization of the human MRE11 homologue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
47. [The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
48. [Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
49. [The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49959)
50. [Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959)