# Mitotic arrest deficient 2 like 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21132390](https://www.wikidata.org/wiki/Q21132390)  
**Source**: https://4ort.xyz/entity/mitotic-arrest-deficient-2-like-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13257)
3. Q20641742
4. [The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
5. [Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
6. [A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
7. [Disruption of FAT10-MAD2 binding inhibits tumor progression.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
8. [HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
9. [Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
10. [p31comet blocks Mad2 activation through structural mimicry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
11. [Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
12. [Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
13. [Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
14. [Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
15. [Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
16. [ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
17. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
18. [Systematic analysis of human protein complexes identifies chromosome segregation proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
19. [Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
20. [Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
21. [Shugoshin is a Mad1/Cdc20-like interactor of Mad2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
22. [Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
23. [Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
24. [Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
25. [The influence of catalysis on mad2 activation dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
26. [Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
27. [Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
28. [Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
29. [Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
30. [Aurora Kinase-A Inactivates DNA Damage-Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
31. [The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
32. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
33. [p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
34. [Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
35. [A protein domain-based interactome network for C. elegans early embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
36. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
37. [Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
38. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
39. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
40. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
41. [Determinants of conformational dimerization of Mad2 and its inhibition by p31comet](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
42. [Defining the human deubiquitinating enzyme interaction landscape](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
43. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
44. [Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13257&geneProductId=UniProtKB:Q13257)
45. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13257&geneProductId=UniProtKB:Q13257)
46. [Identification of a human mitotic checkpoint gene: hsMAD2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
47. [Critical Role of Pcid2 in B Cell Survival through the Regulation of MAD2 Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
48. [Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
49. [The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)
50. [Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257)