# Mitogen-activated protein kinase kinase kinase 8

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21157903](https://www.wikidata.org/wiki/Q21157903)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-kinase-8


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P41279)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
5. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
6. [A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
7. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
8. [NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
9. [ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
10. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
11. [COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
12. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
13. [The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41279&geneProductId=UniProtKB:P41279)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41279&geneProductId=UniProtKB:P41279)
15. [The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
17. [Structure and transforming potential of the human cot oncogene encoding a putative protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279)
18. Ensembl Release 99