# Mitogen-activated protein kinase kinase kinase 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561277](https://www.wikidata.org/wiki/Q28561277)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-kinase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q62925)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
6. [Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
7. [MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
8. [The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
9. [The MEKK 1 PHD ubiquitinates TAB 1 to activate MAPK s in response to cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
10. [MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
11. [Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
12. [Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
13. [Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
14. [MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
15. [MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
16. [Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
17. [Modulation of human cytomegalovirus immediate‐early gene enhancer by mitogen‐activated protein kinase kinase kinase‐1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62925)
18. ensembl Release 104