# mitogen-activated protein kinase kinase kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21170755](https://www.wikidata.org/wiki/Q21170755)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-kinase-1-q21170755


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1097999)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13233)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
6. [Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
7. [FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
8. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
9. [Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
10. [A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
11. [The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
12. [Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
13. [ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
14. [Functional specialization of beta-arrestin interactions revealed by proteomic analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
15. [JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
16. [Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
17. [TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
19. [Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
20. [Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
21. [Expression of the Bcl-2 protein BAD promotes prostate cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13233)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13233&geneProductId=UniProtKB:Q13233)
23. Ensembl Release 99
24. UMLS 2023