# Mitogen-activated protein kinase kinase 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21107535](https://www.wikidata.org/wiki/Q21107535)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-6-q21107535


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P52564)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
6. [Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
7. [C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
8. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
9. [Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
10. [MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
11. [Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
13. [The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52564&geneProductId=UniProtKB:P52564)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52564&geneProductId=UniProtKB:P52564)
15. [Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52564&geneProductId=UniProtKB:P52564)
16. [Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52564&geneProductId=UniProtKB:P52564)
17. [Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52564&geneProductId=UniProtKB:P52564)
18. [Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
19. [Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
20. [Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
21. [Characterization of the structure and function of a novel MAP kinase kinase (MKK6)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
22. [MKK6 controls T3-mediated browning of white adipose tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52564)
23. Ensembl Release 99