# Mitogen-activated protein kinase kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116665](https://www.wikidata.org/wiki/Q21116665)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-2


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P36507)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
6. [Identification of mitogen‐activated protein/extracellular signal‐responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc‐large](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
7. [Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
8. [Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
9. [Identification of interaction between MEK2 and A-Raf-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
10. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
11. [HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
12. [A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
13. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
14. [Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
15. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
16. [Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
17. [The ERK signaling cascade--views from different subcellular compartments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
18. [Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
21. [PEX14 is required for microtubule-based peroxisome motility in human cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507)
22. [The ERK signaling cascade--views from different subcellular compartments](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507)
23. [PEX14 is required for microtubule-based peroxisome motility in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
24. [Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
25. [MiR‐92a mediates AZD6244 induced apoptosis and G1‐phase arrest of lymphoma cells by targeting Bim](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36507)
26. [MiR‐92a mediates AZD6244 induced apoptosis and G1‐phase arrest of lymphoma cells by targeting Bim](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36507&geneProductId=UniProtKB:P36507)
27. Ensembl Release 99
28. UMLS 2023