# Mitogen activated protein kinase kinase 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562571](https://www.wikidata.org/wiki/Q28562571)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q01986)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
6. [Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
7. [Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
8. [MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
9. [Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
10. [Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
11. [The ERK signaling cascade--views from different subcellular compartments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
12. [Insulin enhances growth hormone induction of the MEK/ERK signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
13. [DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
14. [MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
15. [A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
16. [RAF1-activated MEK1 is found on the Golgi apparatus in late prophase and is required for Golgi complex fragmentation in mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
17. [The topography and subcellular distribution of mitogen-activated protein kinase kinase1 (MEK1) in adult rat brain and differentiating PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
18. [PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
19. [ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
20. [Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
21. [Ras and Rap control AMPA receptor trafficking during synaptic plasticity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
22. [Nonspecific inhibition of myogenic tone by PD98059, a MEK1 inhibitor, in rat middle cerebral arteries](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
23. [Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
24. [Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor–Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
25. [ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
26. [MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
27. [Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
28. [MEK/ERK regulates adherens junctions and migration through Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
29. [Regulation of bidirectional melanosome transport by organelle bound MAP kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
30. [Up-regulation of P-TEFb by the MEK1-extracellular signal-regulated kinase signaling pathway contributes to stimulated transcription elongation of immediate early genes in neuroendocrine cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
31. [The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
32. [Signaling via Mitogen-Activated Protein Kinase Kinase (MEK1) Is Required for Golgi Fragmentation during Mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
33. [Regulation of Wallerian degeneration and nerve growth factor withdrawal-induced pruning of axons of sympathetic neurons by the proteasome and the MEK/Erk pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
34. [Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986)
35. ensembl Release 104