# Mitogen-activated protein kinase kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21100360](https://www.wikidata.org/wiki/Q21100360)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-kinase-1-q21100360


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2146883)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3187723)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3182621)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL105442)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1097999)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL507361)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2107832)
10. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q02750)
11. Q20641742
12. [Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
14. [Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
15. [Human tribbles, a protein family controlling mitogen-activated protein kinase cascades](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
16. [VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
17. [Final stages of cytokinesis and midbody ring formation are controlled by BRUCE](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
18. [MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
19. [The Prolyl Isomerase Pin1 Enhances HER-2 Expression and Cellular Transformation via Its Interaction with Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
20. [Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
21. [Spatial regulation of Raf kinase signaling by RKTG](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
22. [A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
23. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
24. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
25. [VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
26. [MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
27. [Regulation of human myoblast differentiation by PEBP4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
28. [An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
29. [Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
30. [Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
31. [Mxi2 promotes stimulus-independent ERK nuclear translocation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
32. [Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
33. [Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
34. [Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
35. [The ERK signaling cascade--views from different subcellular compartments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
36. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02750&geneProductId=UniProtKB:Q02750)
37. [Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02750&geneProductId=UniProtKB:Q02750)
38. [Divergent effects of intrinsically active MEK variants on developmental Ras signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02750&geneProductId=UniProtKB:Q02750)
39. [The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02750&geneProductId=UniProtKB:Q02750)
40. [A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02750&geneProductId=UniProtKB:Q02750)
41. [Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
42. [The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
43. [A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
44. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
45. [Divergent effects of intrinsically active MEK variants on developmental Ras signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
46. [Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
47. [Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
48. [PV1 is a key structural component for the formation of the stomatal and fenestral diaphragms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
49. [MiR‐92a mediates AZD6244 induced apoptosis and G1‐phase arrest of lymphoma cells by targeting Bim](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)
50. [Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750)