# Mitogen-activated protein kinase 8

> mammalian protein found in Mus musculus

**Wikidata**: [Q21979980](https://www.wikidata.org/wiki/Q21979980)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-8


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q91Y86)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91Y86&geneProductId=UniProtKB:Q91Y86)
6. [Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
7. [Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
8. [Gab1 is an integrator of cell death versus cell survival signals in oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
9. [Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
10. [JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
11. [Requirement of the JIP1 scaffold protein for stress-induced JNK activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
12. [Role of interleukin-4 in resistance to Cryptococcus neoformans infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
13. [A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
14. [NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
15. [A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
16. [Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
17. [JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
18. [JNK is required for effector T-cell function but not for T-cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
19. [Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
20. [Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
22. [Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
23. [Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
24. [Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91Y86&geneProductId=UniProtKB:Q91Y86)
25. [The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91Y86&geneProductId=UniProtKB:Q91Y86)
26. [Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91Y86&geneProductId=UniProtKB:Q91Y86)
27. [Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91Y86&geneProductId=UniProtKB:Q91Y86)
28. [The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
29. [Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
30. [The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
31. [Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
32. [Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
33. [Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
34. [Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
35. [JNK regulates the photic response of the mammalian circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
36. [A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
37. [JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
38. [Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91Y86&geneProductId=UniProtKB:Q91Y86)
39. [Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
40. [SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
41. [A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91Y86)
42. [JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91Y86&geneProductId=UniProtKB:Q91Y86)
43. ensembl Release 106