# mitogen-activated protein kinase 8

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6714411](https://www.wikidata.org/wiki/Q6714411)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-8-q6714411


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1950289)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P45983)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P45983&geneProductId=UniProtKB:P45983)
8. [JNK1 phosphorylates SIRT1 and promotes its enzymatic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
9. [Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
10. [JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
11. [The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
12. [Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
13. [The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
14. [c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
15. [Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
16. [The JIP group of mitogen-activated protein kinase scaffold proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
17. [Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
18. [Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
19. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
20. [The tyrosine kinase Syk regulates TPL2 activation signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
21. [A selective small-molecule inhibitor of c-Jun N-terminal kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
22. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
23. [HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
24. [3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
25. [Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
26. [Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
27. [c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
28. [A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
29. [Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
30. [Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
31. [Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
32. [Selective interaction of JNK protein kinase isoforms with transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
33. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
34. [JNK1 phosphorylates SIRT1 and promotes its enzymatic activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P45983&geneProductId=UniProtKB:P45983)
35. [Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
36. [JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=P45983&geneProductId=UniProtKB:P45983)
37. [Expression of the Bcl-2 protein BAD promotes prostate cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
38. [Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
39. [HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
40. [SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
41. [Regulation of autophagy by Beclin 1 in the heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
42. [JNK regulates the photic response of the mammalian circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
43. [JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
44. [Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
45. [Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983)
46. Ensembl Release 99
47. UMLS 2023