# Mitogen-activated protein kinase 8

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28560466](https://www.wikidata.org/wiki/Q28560466)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-8-q28560466


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49185)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
5. [Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
6. [Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
7. [Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
9. [JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
10. [JNK1 Inhibits GluR1 Expression and GluR1-Mediated Calcium Influx through Phosphorylation and Stabilization of Hes-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
11. [Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
12. [Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
13. [JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
14. [Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
15. [JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
16. [JNK (c-Jun NH2 terminal kinase) and p38 during ischemia reperfusion injury in the small intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
17. [c-Jun N-terminal kinase (JNK) and JNK interacting protein response in rat brain after transient middle cerebral artery occlusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
18. [Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
19. [Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
20. [c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
21. [Hypoosmotic stress activates p38, ERK 1 and 2, and SAPK/JNK in rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
22. [Cellular signalling after in vivo heat shock in the liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
23. [Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
24. [JNK phosphorylates paxillin and regulates cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
25. [Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
26. [Regulation of c-Jun N-terminal kinase activation in hydrogen peroxide induced neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
27. [p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
28. [A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
29. [The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
30. [Regulation of Cytokine-Induced Neuron Death by Ovarian Hormones: Involvement of Antiapoptotic Protein Expression and c-JUN N-Terminal Kinase-Mediated Proapoptotic Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
31. [TNFalpha induces apoptosis through JNK/Bax-dependent pathway in differentiated, but not naïve PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
32. [Activation of c-Jun NH2-terminal kinases by interleukin-1β in normal human osteoblastic and rat UMR-106 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
33. [JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49185)
34. ensembl Release 104