# mitogen-activated protein kinase 3

> extracellular signal-regulated MAP kinase that phosphorylates a number of transcription factors and microtubule-associated proteins

**Wikidata**: [Q6714406](https://www.wikidata.org/wiki/Q6714406)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-3


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3544964)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3590106)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P27361)
5. Q20641742
6. [Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361)
9. [Molecular Cloning, Expression, and Characterization of the Human Mitogen-Activated Protein Kinase p44erk1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361)
10. [Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361)
11. [Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
12. [Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
13. [Erk phosphorylates threonine 42 residue of ribosomal protein S3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
14. [c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
15. [Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
16. [Phosphorylation of myofibrillogenesis regulator‐1 activates the MAPK signaling pathway and induces proliferation and migration in human breast cancer MCF7 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
17. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
18. [The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
19. [SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
20. [The tyrosine kinase Syk regulates TPL2 activation signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
21. [Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
22. [DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
23. [Regulation of human myoblast differentiation by PEBP4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
24. [Large-scale structural analysis of the classical human protein tyrosine phosphatome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
25. [Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
26. [Inactivation of mitogen-activated protein kinases by a mammalian tyrosine-specific phosphatase, PTPBR7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
27. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
28. [Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
29. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
30. [A directed protein interaction network for investigating intracellular signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
31. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
32. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
33. [ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
34. [Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
35. [Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
36. [Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
37. [Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
38. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361)
39. [Molecular Cloning, Expression, and Characterization of the Human Mitogen-Activated Protein Kinase p44erk1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
40. [Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
41. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
42. [The ERK signaling cascade--views from different subcellular compartments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
43. [A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
44. [The ERK signaling cascade--views from different subcellular compartments](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361)
45. [Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
46. [High-throughput RNAi screening reveals novel regulators of telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
47. [Expression of the Bcl-2 protein BAD promotes prostate cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
48. [Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
49. [Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)
50. [PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361)