# mitogen-activated protein kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6590503](https://www.wikidata.org/wiki/Q6590503)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-1


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3544964)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3590106)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P28482)
5. Q20641742
6. [Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P28482)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
8. [The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
9. [Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
10. [Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
11. [Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
12. [MFAP3L activation promotes colorectal cancer cell invasion and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
13. [Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
14. [A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
15. [Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
16. [Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
17. [Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
18. [Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
19. [Mxi2 promotes stimulus-independent ERK nuclear translocation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
20. [ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
21. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
22. [TRAPPC4-ERK2 Interaction Activates ERK1/2, Modulates Its Nuclear Localization and Regulates Proliferation and Apoptosis of Colorectal Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
23. [Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
24. [Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
25. [The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
26. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
27. [Activation of Extracellular Signal-regulated Kinase 2 by a Novel Abl-binding Protein, ST5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
28. [Functional specialization of beta-arrestin interactions revealed by proteomic analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
29. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
30. [Phosphorylation of U24 from Human Herpes Virus type 6 (HHV-6) and its potential role in mimicking myelin basic protein (MBP) in multiple sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
31. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
32. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
33. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
34. [MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
35. [New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
36. [Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
37. [A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
38. [ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
39. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
40. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28482&geneProductId=UniProtKB:P28482)
41. [Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28482&geneProductId=UniProtKB:P28482)
42. [The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28482&geneProductId=UniProtKB:P28482)
43. [Regulation of Microtubule Assembly by Tau and not by Pin1.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28482&geneProductId=UniProtKB:P28482)
44. [Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
45. [Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
46. [Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
47. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
48. [The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
49. [Regulation of Microtubule Assembly by Tau and not by Pin1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482)
50. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P28482)