# Mitogen activated protein kinase 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28557382](https://www.wikidata.org/wiki/Q28557382)  
**Source**: https://4ort.xyz/entity/mitogen-activated-protein-kinase-1-q28557382


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P63086)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
5. [Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P63086&geneProductId=UniProtKB:P63086)
7. [Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=P63086&geneProductId=UniProtKB:P63086)
8. [Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P63086&geneProductId=UniProtKB:P63086)
9. [Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
10. [Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
11. [LysRS serves as a key signaling molecule in the immune response by regulating gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
12. [ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
13. [Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
15. [MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
16. [DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
17. [Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
18. [Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
19. [Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
20. [CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
21. [Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
22. [cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
23. [The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
24. [Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
25. [The ERK signaling cascade--views from different subcellular compartments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
26. [Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
27. [ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
28. [Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
29. [Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
30. [Altered Extracellular Signal-regulated Kinase Signal Transduction by the Muscarinic Acetylcholine and Metabotropic Glutamate Receptors after Cerebral Ischemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
31. [Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
32. [The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
33. [MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
34. [Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
35. [Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
36. [Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
37. [1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
38. [Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
39. [Ovarian steroid receptors and activated MAPK in the regional decidualization in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
40. [MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
41. [Acrolein activates mitogen-activated protein kinase signal transduction pathways in rat vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63086)
42. ensembl Release 106