# Mitochondrial antiviral signaling protein

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21104831](https://www.wikidata.org/wiki/Q21104831)  
**Source**: https://4ort.xyz/entity/mitochondrial-antiviral-signaling-protein


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q7Z434)
3. Q20641742
4. [Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
5. [Peroxisomes are signaling platforms for antiviral innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
7. [Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
8. [GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
9. [ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
10. [The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
11. [IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
12. [Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination-dependent Manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
13. [PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
14. [Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
15. [The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
16. [Mitochondrially localised MUL1 is a novel modulator of antiviral signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
17. [Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
18. [The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
19. [Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
20. [Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
21. [Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
22. [Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
23. [Nlrp6 regulates intestinal antiviral innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
24. [Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
25. [Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
26. [Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
27. [Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
28. [ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
29. [Hepatitis B Virus Regulatory HBx Protein Binds to Adaptor Protein IPS-1 and Inhibits the Activation of Beta Interferon](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
30. [Human metapneumovirus M2-2 protein inhibits innate cellular signaling by targeting MAVS](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
31. [Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
32. [c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
33. [DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
34. [The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
35. [MAVS Protein Is Attenuated by Rotavirus Nonstructural Protein 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
36. [Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
37. [STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
38. [Activation of STAT6 by STING is critical for antiviral innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
39. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
40. [WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
41. [Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
42. [NLRX1 is a regulator of mitochondrial antiviral immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
43. [Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
44. [Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
45. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
46. [The Atg5 Atg12 conjugate associates with innate antiviral immune responses](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
47. [Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
48. [Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
49. [IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)
50. [The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434)