# microtubule associated protein tau

> mammalian protein found in Homo sapiens

**Wikidata**: [Q419507](https://www.wikidata.org/wiki/Q419507)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Tau_protein)  
**Source**: https://4ort.xyz/entity/microtubule-associated-protein-tau


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P10636)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
6. [Tau interacts with src-family non-receptor tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
8. [Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
9. [Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
10. [LRRK2 Promotes Tau Accumulation, Aggregation and Release.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
11. [Tau promoter confers neuronal specificity and binds Sp1 and AP-2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
12. [Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
13. [Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
14. [Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
15. [Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
16. [Akt and CHIP coregulate tau degradation through coordinated interactions](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
17. [Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
18. [Effect of phosphorylation on interaction of human tau protein with 14-3-3zeta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
19. [14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
20. [Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
21. [Impact of the Cellular Prion Protein on Amyloid-β and 3PO-Tau Processing](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
22. [Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
23. [Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
24. [Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
25. [Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
26. [Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
27. [PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
28. [Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
29. [Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
30. [Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
31. [Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
32. [Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
33. [A role for FKBP52 in Tau protein function](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636)
34. [Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636)
35. [Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636)
36. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636)
37. [Tau physiology and pathomechanisms in frontotemporal lobar degeneration](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
38. [Tau promotes neurodegeneration via DRP1 mislocalization in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
39. [Roles of tau protein in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
40. [The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636)
41. [Tau protein binds to microtubules through a flexible array of distributed weak sites](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636)
42. [The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
43. [Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636)
44. [Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
45. [Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
46. [Tau protein binds to microtubules through a flexible array of distributed weak sites](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
47. [Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
48. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
49. [Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)
50. [Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636)