Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P361
  value: formate-tetrahydrofolate ligase
additional property: PropertyValue
  property ID: P361
  value: NAD(P)-binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Tetrahydrofolate dehydrogenase/cyclohydrolase
additional property: PropertyValue
  property ID: P527
  value: Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
additional property: PropertyValue
  property ID: P527
  value: Formate-tetrahydrofolate ligase, FTHFS, conserved site
additional property: PropertyValue
  property ID: P527
  value: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
additional property: PropertyValue
  property ID: P637
  value: NP_001164256
additional property: PropertyValue
  property ID: P637
  value: NP_001164257
additional property: PropertyValue
  property ID: P637
  value: NP_758512
additional property: PropertyValue
  property ID: P638
  value: 2EO2
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: formate-tetrahydrofolate ligase activity
additional property: PropertyValue
  property ID: P680
  value: ligase activity
additional property: PropertyValue
  property ID: P681
  value: mitochondrion
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: mitochondrion
additional property: PropertyValue
  property ID: P682
  value: embryonic neurocranium morphogenesis
additional property: PropertyValue
  property ID: P682
  value: embryonic viscerocranium morphogenesis
additional property: PropertyValue
  property ID: P682
  value: tetrahydrofolate interconversion
additional property: PropertyValue
  property ID: P702
  value: Mthfd1l
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000036178
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000112870
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000112897
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 14
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 14
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q3V3R1
    source count: 1
    confidence: 0.2
  P361:
    value: Q24776360
    source count: 1
    confidence: 0.2
    value label: formate-tetrahydrofolate ligase
  P361:
    value: Q41797412
    source count: 1
    confidence: 0.2
    value label: NAD(P)-binding domain superfamily
  P361:
    value: Q24784799
    source count: 1
    confidence: 0.2
    value label: Tetrahydrofolate dehydrogenase/cyclohydrolase
  P361:
    value: Q24726930
    source count: 1
    confidence: 0.2
    value label: P-loop containing nucleoside triphosphate hydrolase
  P361:
    value: Q83137500
    source count: 1
    confidence: 0.2
    value label: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain, protein family
  P527:
    value: Q24774915
    source count: 1
    confidence: 0.2
    value label: Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  P527:
    value: Q24777026
    source count: 1
    confidence: 0.2
    value label: Formate-tetrahydrofolate ligase, FTHFS, conserved site
  P527:
    value: Q24742125
    source count: 1
    confidence: 0.2
    value label: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
  P637:
    value: NP_001164256
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001164257
    source count: 1
    confidence: 0.2
  P637:
    value: NP_758512
    source count: 1
    confidence: 0.2
  P637:
    value: XP_036011688
    source count: 1
    confidence: 0.2
  P637:
    value: XP_036011689
    source count: 1
    confidence: 0.2
  P638:
    value: 2EO2
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q21111746
    source count: 4
    confidence: 0.8
    value label: formate-tetrahydrofolate ligase activity
  P680:
    value: Q14861871
    source count: 1
    confidence: 0.2
    value label: ligase activity
  P680:
    value: Q14817981
    source count: 3
    confidence: 0.6
    value label: ATP binding
  P680:
    value: Q14762996
    source count: 1
    confidence: 0.2
    value label: protein homodimerization activity

value: Q39572
source count: 5
confidence: 1.0
value label: mitochondrion

value: Q79899
source count: 1
confidence: 0.2
value label: cytoplasm

value: Q39572
source count: 6
confidence: 1.0
value label: mitochondrion

value: Q14897664
source count: 1
confidence: 0.2
value label: embryonic neurocranium morphogenesis

value: Q14897665
source count: 1
confidence: 0.2
value label: embryonic viscerocranium morphogenesis

value: Q14864919
source count: 1
confidence: 0.2
value label: tetrahydrofolate interconversion

value: Q14885826
source count: 1
confidence: 0.2
value label: neural tube closure

value: Q21131856
source count: 1
confidence: 0.2
value label: formate metabolic process

value: Q18301070
source count: 1
confidence: 0.2
value label: Mthfd1l

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000036178
source count: 1
confidence: 0.2

value: ENSMUSP00000112870
source count: 1
confidence: 0.2

value: ENSMUSP00000112897
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls
stated in qid: Q24317651
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-31

source: Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls
stated in qid: Q24317651
retrieved: 2018-01-31

source: A mitochondrial protein compendium elucidates complex I disease biology
stated in qid: Q24655079
retrieved: 2018-01-31

source: Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos
stated in qid: Q28506233
retrieved: 2018-01-31

source: Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos
stated in qid: Q28506233
retrieved: 2019-02-14

source: A mitochondrial protein compendium elucidates complex I disease biology
stated in qid: Q24655079
retrieved: 2019-02-14

source: Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice
stated in qid: Q28594629
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21494887
domain: protein
level: standard
html url: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-nadp-dependent-1-like-q21494887
markdown url: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-nadp-dependent-1-like-q21494887.md
facts url summary: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-nadp-dependent-1-like-q21494887/facts.json
facts url standard: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-nadp-dependent-1-like-q21494887/facts.json
facts url full: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-nadp-dependent-1-like-q21494887/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T02:04:30.087245Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:40:56.656023+00:00Z