Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P11586
additional property: PropertyValue
  property ID: P361
  value: formate-tetrahydrofolate ligase
additional property: PropertyValue
  property ID: P361
  value: NAD(P)-binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Tetrahydrofolate dehydrogenase/cyclohydrolase
additional property: PropertyValue
  property ID: P373
  value: MTHFD1
additional property: PropertyValue
  property ID: P527
  value: Formate-tetrahydrofolate ligase, FTHFS, conserved site
additional property: PropertyValue
  property ID: P527
  value: Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
additional property: PropertyValue
  property ID: P527
  value: Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
additional property: PropertyValue
  property ID: P637
  value: NP_005947
additional property: PropertyValue
  property ID: P637
  value: NP_001351766
additional property: PropertyValue
  property ID: P638
  value: 1A4I
additional property: PropertyValue
  property ID: P638
  value: 1DIA
additional property: PropertyValue
  property ID: P638
  value: 1DIB
additional property: PropertyValue
  property ID: P646
  value: /m/03gxpby
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: methylenetetrahydrofolate dehydrogenase (NADP+) activity
additional property: PropertyValue
  property ID: P680
  value: methylenetetrahydrofolate dehydrogenase (NAD+) activity
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: mitochondrion
additional property: PropertyValue
  property ID: P681
  value: extracellular exosome
additional property: PropertyValue
  property ID: P682
  value: purine nucleotide biosynthetic process
additional property: PropertyValue
  property ID: P682
  value: transsulfuration
additional property: PropertyValue
  property ID: P682
  value: neutrophil homeostasis
additional property: PropertyValue
  property ID: P702
  value: MTHFD1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000450560
additional property: PropertyValue
  property ID: P705
  value: ENSP00000438588
additional property: PropertyValue
  property ID: P705
  value: ENSP00000476468
additional property: PropertyValue
  property ID: P6366
  value: 2779013074
confidence:
  popularity graph score:
    score: 0.007
    score pct: 1
    tier: established
    components:
      sitelinks: 5
      sitelinks norm: 0.012
      unique citations: 23
      unique citations norm: 0.009
      monthly pageviews: 24
      monthly pageviews norm: 0.0
  sitelinks: 5
  unique citations: 23
  monthly pageviews: 24
  yearly pageviews: 48
  pageview trend:
    m: 2026-08
    v: 24
  pageview trend:
    m: 2026-07
    v: 5
  pageview trend:
    m: 2026-06
    v: 9
  pageview trend:
    m: 2026-05
    v: 1
  pageview trend:
    m: 2026-05
    v: 1
  pageview trend:
    m: 2026-04
    v: 8
  popularity:
    sitelinks: 5
    max: 423
    pct: 1.2
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P11586
    source count: 1
    confidence: 0.2
  P361:
    value: Q24776360
    source count: 1
    confidence: 0.2
    value label: formate-tetrahydrofolate ligase
  P361:
    value: Q41797412
    source count: 1
    confidence: 0.2
    value label: NAD(P)-binding domain superfamily
  P361:
    value: Q24784799
    source count: 1
    confidence: 0.2
    value label: Tetrahydrofolate dehydrogenase/cyclohydrolase
  P361:
    value: Q24726930
    source count: 1
    confidence: 0.2
    value label: P-loop containing nucleoside triphosphate hydrolase
  P361:
    value: Q83137500
    source count: 1
    confidence: 0.2
    value label: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain, protein family
  P373:
    value: MTHFD1
    source count: 0
    confidence: 0.0
  P527:
    value: Q24777026
    source count: 1
    confidence: 0.2
    value label: Formate-tetrahydrofolate ligase, FTHFS, conserved site
  P527:
    value: Q24774915
    source count: 1
    confidence: 0.2
    value label: Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  P527:
    value: Q24787735
    source count: 1
    confidence: 0.2
    value label: Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
  P527:
    value: Q24742125
    source count: 1
    confidence: 0.2
    value label: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
  P637:
    value: NP_005947
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001351766
    source count: 1
    confidence: 0.2
  P638:
    value: 1A4I
    source count: 1
    confidence: 0.2

value: 1DIA
source count: 1
confidence: 0.2

value: 1DIB
source count: 1
confidence: 0.2

value: 1DIG
source count: 1
confidence: 0.2

value: /m/03gxpby
source count: 0
confidence: 0.0

value: Q14860365
source count: 1
confidence: 0.2
value label: nucleotide binding

value: Q21111750
source count: 3
confidence: 0.6
value label: methylenetetrahydrofolate dehydrogenase (NADP+) activity

value: Q21111749
source count: 2
confidence: 0.4
value label: methylenetetrahydrofolate dehydrogenase (NAD+) activity

value: Q14861871
source count: 1
confidence: 0.2
value label: ligase activity

value: Q21111748
source count: 2
confidence: 0.4
value label: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q39572
source count: 2
confidence: 0.4
value label: mitochondrion

value: Q903634
source count: 4
confidence: 0.8
value label: extracellular exosome

value: Q79899
source count: 2
confidence: 0.4
value label: cytoplasm

value: Q220599
source count: 2
confidence: 0.4
value label: cytosol

value: Q14864590
source count: 2
confidence: 0.4
value label: purine nucleotide biosynthetic process

value: Q14913085
source count: 1
confidence: 0.2
value label: transsulfuration

value: Q14908216
source count: 1
confidence: 0.2
value label: neutrophil homeostasis

value: Q14819379
source count: 2
confidence: 0.4
value label: one-carbon metabolic process

value: Q14914213
source count: 2
confidence: 0.4
value label: serine family amino acid metabolic process

value: Q18029537
source count: 1
confidence: 0.2
value label: MTHFD1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000450560
source count: 1
confidence: 0.2

value: ENSP00000438588
source count: 1
confidence: 0.2

value: ENSP00000476468
source count: 1
confidence: 0.2

value: ENSP00000477199
source count: 1
confidence: 0.2

value: ENSP00000477359
source count: 1
confidence: 0.2

value: 2779013074
source count: 0
confidence: 0.0

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2017-09-26

source: Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase
stated in qid: Q28116078
retrieved: 2017-09-26

source: Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches
stated in qid: Q28115639
retrieved: 2019-04-08

source: Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase
stated in qid: Q28116078
retrieved: 2019-04-08

source: Expression of active domains of a human folate-dependent trifunctional enzyme in Escherichia coli
stated in qid: Q45364567
retrieved: 2019-04-08

source: Defining the membrane proteome of NK cells
stated in qid: Q24323157
retrieved: 2017-09-26

source: Purification and characterization of a mitochondrial isozyme of C1-tetrahydrofolate synthase from Saccharomyces cerevisiae
stated in qid: Q27936262
retrieved: 2017-09-26

source: Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
stated in qid: Q24313258
retrieved: 2017-09-26

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2017-09-26

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2017-09-26

source: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
stated in qid: Q24311780
retrieved: 2017-09-26

source: Purification and characterization of a mitochondrial isozyme of C1-tetrahydrofolate synthase from Saccharomyces cerevisiae
stated in qid: Q27936262
retrieved: 2019-04-08

source: Defining the membrane proteome of NK cells
stated in qid: Q24323157
retrieved: 2019-04-08

source: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
stated in qid: Q24311780
retrieved: 2019-04-08

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2019-04-08

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2019-04-08

source: Characterization and review of MTHFD1 deficiency: four new patients, cellular delineation and response to folic and folinic acid treatment
stated in qid: Q24316931
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21111753
domain: protein
level: standard
html url: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1
markdown url: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1.md
facts url summary: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1/facts.json
facts url standard: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1/facts.json
facts url full: https://4ort.xyz/entity/methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-10T15:25:22.994756Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-04-11T00:01:31.698717+00:00Z